Literature DB >> 14668425

Can new neurons replace memories lost?

Tracey J Shors1.   

Abstract

It now appears that new neurons are produced not only in the healthy adult brain but also in the brains of patients with Alzheimer's disease (AD). Although the function of new neurons in the healthy brain is unknown, there is evidence that they are involved in certain types of memory formation and that their survival is enhanced dramatically and persistently by learning experiences. The evidence that neurogenesis, or at least the expression of proteins unique to immature neurons, occurs during the late stages of AD raises the possibility that their production could be enhanced earlier in the disease process before so many neurons and memories are lost.

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Year:  2003        PMID: 14668425      PMCID: PMC3364675          DOI: 10.1126/sageke.2003.49.pe35

Source DB:  PubMed          Journal:  Sci Aging Knowledge Environ        ISSN: 1539-6150


  18 in total

1.  Neurogenesis in the adult is involved in the formation of trace memories.

Authors:  T J Shors; G Miesegaes; A Beylin; M Zhao; T Rydel; E Gould
Journal:  Nature       Date:  2001-03-15       Impact factor: 49.962

2.  The role of the hippocampus in trace conditioning: temporal discontinuity or task difficulty?

Authors:  A V Beylin; C C Gandhi; G E Wood; A C Talk; L D Matzel; T J Shors
Journal:  Neurobiol Learn Mem       Date:  2001-11       Impact factor: 2.877

3.  Increased hippocampal neurogenesis in Alzheimer's disease.

Authors:  Kunlin Jin; Alyson L Peel; Xiao Ou Mao; Lin Xie; Barbara A Cottrell; David C Henshall; David A Greenberg
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-05       Impact factor: 11.205

4.  Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors.

Authors:  Hirofumi Nakatomi; Toshihiko Kuriu; Shigeo Okabe; Shin-ichi Yamamoto; Osamu Hatano; Nobutaka Kawahara; Akira Tamura; Takaaki Kirino; Masato Nakafuku
Journal:  Cell       Date:  2002-08-23       Impact factor: 41.582

5.  Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats.

Authors:  J Altman; G D Das
Journal:  J Comp Neurol       Date:  1965-06       Impact factor: 3.215

6.  Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus.

Authors:  H van Praag; G Kempermann; F H Gage
Journal:  Nat Neurosci       Date:  1999-03       Impact factor: 24.884

7.  Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus.

Authors:  J E Malberg; A J Eisch; E J Nestler; R S Duman
Journal:  J Neurosci       Date:  2000-12-15       Impact factor: 6.167

8.  Neurogenesis may relate to some but not all types of hippocampal-dependent learning.

Authors:  Tracey J Shors; David A Townsend; Mingrui Zhao; Yevgenia Kozorovitskiy; Elizabeth Gould
Journal:  Hippocampus       Date:  2002       Impact factor: 3.899

9.  Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat.

Authors:  T M Madsen; P E G Kristjansen; T G Bolwig; G Wörtwein
Journal:  Neuroscience       Date:  2003       Impact factor: 3.590

10.  Functional neurogenesis in the adult hippocampus.

Authors:  Henriette van Praag; Alejandro F Schinder; Brian R Christie; Nicolas Toni; Theo D Palmer; Fred H Gage
Journal:  Nature       Date:  2002-02-28       Impact factor: 69.504

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