H G van der Poel1. 1. Department Urology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. h.vd.poel@nki.nl
Abstract
OBJECTIVES: Growth signaling is instrumental in tumor development. Insight into signaling pathways by molecular and cellular biology has changed the development of new anticancer agents. Outside the field of urology specifically targeted drugs such as imatinib mesylate and gefitinib showed impressive anticancer activity in chronic myeloid leukemia and non-small cell lung cancer, respectively. METHODS: Literature search of PubMed documented publications and abstracts from meetings. RESULTS: Preclinical data in prostate cancer shows upregulation of a wide variety of growth factors and their receptors such as PDGF, EGF, IGF, FGF, and VEGF suggesting efficacy of agents targeting these pathways. Here the preclinical evidence and first clinical data on the use of growth signal targeting in prostate cancer is reviewed. Although some anticancer efficacy of signal transduction inhibition monotherapy was reported, combination with chemotherapy and radiotherapy seemed most promising in prostate cancer. CONCLUSION: So-called smart drugs are small molecules targeted at specific growth signaling pathways. These new drugs will dominate clinical trials in the years to come either as single-drug modality, but more likely as combination treatment.
OBJECTIVES: Growth signaling is instrumental in tumor development. Insight into signaling pathways by molecular and cellular biology has changed the development of new anticancer agents. Outside the field of urology specifically targeted drugs such as imatinib mesylate and gefitinib showed impressive anticancer activity in chronic myeloid leukemia and non-small cell lung cancer, respectively. METHODS: Literature search of PubMed documented publications and abstracts from meetings. RESULTS: Preclinical data in prostate cancer shows upregulation of a wide variety of growth factors and their receptors such as PDGF, EGF, IGF, FGF, and VEGF suggesting efficacy of agents targeting these pathways. Here the preclinical evidence and first clinical data on the use of growth signal targeting in prostate cancer is reviewed. Although some anticancer efficacy of signal transduction inhibition monotherapy was reported, combination with chemotherapy and radiotherapy seemed most promising in prostate cancer. CONCLUSION: So-called smart drugs are small molecules targeted at specific growth signaling pathways. These new drugs will dominate clinical trials in the years to come either as single-drug modality, but more likely as combination treatment.
Authors: M Katie Conley-LaComb; Wei Huang; Shihua Wang; Dongping Shi; Young Suk Jung; Abdo Najy; Rafael Fridman; R Daniel Bonfil; Michael L Cher; Yong Q Chen; Hyeong-Reh Choi Kim Journal: Am J Pathol Date: 2011-12-28 Impact factor: 4.307
Authors: Li Zhang; Jeffrey S Davis; Stanislav Zelivianski; Fen-Fen Lin; Rachel Schutte; Thomas L Davis; Ralph Hauke; Surinder K Batra; Ming-Fong Lin Journal: Cancer Lett Date: 2009-05-24 Impact factor: 8.679
Authors: W Huang; Y Fridman; R D Bonfil; C V Ustach; M K Conley-LaComb; C Wiesner; A Saliganan; M L Cher; H-R C Kim Journal: Oncogene Date: 2011-12-12 Impact factor: 9.867