| Literature DB >> 14667507 |
Jindong Chen1, Weng-Onn Lui, Michele D Vos, Geoffrey J Clark, Masayuki Takahashi, Jacqueline Schoumans, Sok Kean Khoo, David Petillo, Todd Lavery, Jun Sugimura, Dewi Astuti, Chun Zhang, Susumu Kagawa, Eamonn R Maher, Catharina Larsson, Arthur S Alberts, Hiro-omi Kanayama, Bin Tean Teh.
Abstract
By positional cloning, we identified two breakpoint-spanning genes in a familial clear cell renal cell carcinoma (CCRCC)-associated t(1;3)(q32.1;q13.3): LSAMP and NORE1 (RASSF1 homolog). Both genes are downregulated in 9 of 9 RCC cell lines. While the NORE1A promoter predominantly presents partial methylation in 6 of the cell lines and 17/53 (32%) primary tumors, the LSAMP promoter is completely methylated in 5 of 9 cell lines and in 14/53 (26%) sporadic and 4 familial CCRCCs. Expression of LSAMP and NORE1A proteins in CCRCC cell lines inhibited cell proliferation. These characteristics indicate that LSAMP and NORE1A may represent new candidate tumor suppressors for CCRCC.Entities:
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Year: 2003 PMID： 14667507 DOI： 10.1016/s1535-6108(03)00269-1
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743