BACKGROUND: An increased number of dendritic cells (DCs), as indicated by positive S-100 protein staining, has been shown to correlate with good prognosis in several malignancies. The clinicopathological significance of S-100 protein-positive cells in human colorectal cancer is unclear and was thus examined. PATIENTS AND METHODS: We investigated the relationships between the density of S-100 protein-positive cells at the peripheral area of the tumor, prognosis and clinicopathological factors in 30 patients with colorectal cancer. S-100 protein-positive cells were detected by immunohistochemistry using a mouse monoclonal antibody against S-100 protein. RESULTS: The number of S-100 protein-positive cells was significantly higher in patients with a good prognosis or those without recurrence or worsening of their condition, but was significantly lower in patients with lymph node metastasis, T3-T4, hepatic metastasis or tumors more advanced than stage III (TNM). CONCLUSION: S-100 protein-positive cells may act as one line of defense against malignant cells in patients with colorectal cancer.
BACKGROUND: An increased number of dendritic cells (DCs), as indicated by positive S-100 protein staining, has been shown to correlate with good prognosis in several malignancies. The clinicopathological significance of S-100 protein-positive cells in humancolorectal cancer is unclear and was thus examined. PATIENTS AND METHODS: We investigated the relationships between the density of S-100 protein-positive cells at the peripheral area of the tumor, prognosis and clinicopathological factors in 30 patients with colorectal cancer. S-100 protein-positive cells were detected by immunohistochemistry using a mouse monoclonal antibody against S-100 protein. RESULTS: The number of S-100 protein-positive cells was significantly higher in patients with a good prognosis or those without recurrence or worsening of their condition, but was significantly lower in patients with lymph node metastasis, T3-T4, hepatic metastasis or tumors more advanced than stage III (TNM). CONCLUSION:S-100 protein-positive cells may act as one line of defense against malignant cells in patients with colorectal cancer.
Authors: Anastassios C Manolakis; Andreas N Kapsoritakis; Elisavet K Tiaka; Spyros P Potamianos Journal: Dig Dis Sci Date: 2011-01-04 Impact factor: 3.199
Authors: Felix Wagner; Ulrike Hölig; Friederike Wilczkowski; Ioana Plesca; Ulrich Sommer; Rebekka Wehner; Maximilian Kießler; Armin Jarosch; Katharina Flecke; Maia Arsova; Antje Tunger; Andreas Bogner; Christoph Reißfelder; Jürgen Weitz; Knut Schäkel; Esther G C Troost; Mechthild Krause; Gunnar Folprecht; Martin Bornhäuser; Michael P Bachmann; Daniela Aust; Gustavo Baretton; Marc Schmitz Journal: Front Immunol Date: 2019-03-29 Impact factor: 7.561