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Literature DB >> 14666403

Genomewide linkage analysis of familial prostate cancer in the Japanese population.

Hiroshi Matsui^1,2, Kazuhiro Suzuki², Nobuaki Ohtake², Seiji Nakata², Toshiyuki Takeuchi³, Hidetoshi Yamanaka², Ituro Inoue⁴.

Abstract

Prostate cancer (PC) is one of the most common causes of cancer mortality in Western countries, and familial aggregation of PC is well known. Multiple PC susceptibility loci have been reported in Western countries, but attempts to confirm the loci in independent data sets have proven to be inconsistent. We performed a genomewide linkage analysis with 53 affected sib pairs to identify genetic loci related to PC in a Japanese population. Two linkage analyses, GENEHUNTER-PLUS and SIBPAL, were applied and detected nominal statistical significance of linkage to PC at chromosome 1p and 8p, which were reported as being loci for PC in Caucasians. The best evidence of linkage was detected near D8S550 on 8p23 (maximum Zlr=2.25, P=0.037), and the second-best evidence of linkage was observed near D1S2667 on 1p36 (maximum Zlr=2.24, P=0.034). This is the first genetic mapping of PC in Japanese, and the results suggest that susceptibilities to PC lie close to D8S550 on 8p23 and D1S2667 on 1p36.

Entities: Disease

Mesh：

Year: 2003 PMID： 14666403 DOI： 10.1007/s10038-003-0099-y

Source DB: PubMed Journal: J Hum Genet ISSN： 1434-5161 Impact factor: 3.172

40 in total

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Review 10. Androgens and the control of lipid metabolism in human prostate cancer cells.

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19 in total

1. A common nonsense mutation in EphB2 is associated with prostate cancer risk in African American men with a positive family history.

Authors: R A Kittles; A B Baffoe-Bonnie; T Y Moses; C M Robbins; C Ahaghotu; P Huusko; C Pettaway; S Vijayakumar; J Bennett; G Hoke; T Mason; S Weinrich; J M Trent; F S Collins; S Mousses; J Bailey-Wilson; P Furbert-Harris; G Dunston; I J Powell; J D Carpten
Journal: J Med Genet Date: 2005-09-09 Impact factor: 6.318

2. Shared genomic segment analysis. Mapping disease predisposition genes in extended pedigrees using SNP genotype assays.

Authors: A Thomas; N J Camp; J M Farnham; K Allen-Brady; L A Cannon-Albright
Journal: Ann Hum Genet Date: 2007-12-18 Impact factor: 1.670

Genomewide linkage analysis of familial prostate cancer in the Japanese population.

1. Model-free linkage analysis with covariates confirms linkage of prostate cancer to chromosomes 1 and 4.

2. Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36.

3. Parametric and nonparametric linkage analysis: a unified multipoint approach.

4. Cancer statistics, 1997.

5. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results.

6. Germline mutations in the ribonuclease L gene in families showing linkage with HPC1.

7. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers.

8. A candidate prostate cancer susceptibility gene at chromosome 17p.

9. Homozygous deletion and frequent allelic loss of chromosome 8p22 loci in human prostate cancer.

Review 10. Androgens and the control of lipid metabolism in human prostate cancer cells.

1. A common nonsense mutation in EphB2 is associated with prostate cancer risk in African American men with a positive family history.

2. Shared genomic segment analysis. Mapping disease predisposition genes in extended pedigrees using SNP genotype assays.

Review 3. Prostate cancer susceptibility loci: finding the genes.

Review 4. Molecular mechanisms involving prostate cancer racial disparity.

Review 5. Prostate Cancer Genetics: Variation by Race, Ethnicity, and Geography.

Review 6. Metabolic alterations and targeted therapies in prostate cancer.

Review 7. New strategies in prostate cancer: targeting lipogenic pathways and the energy sensor AMPK.

Review 8. Prostate Cancer Disparities by Race and Ethnicity: From Nucleotide to Neighborhood.

9. Molecular mechanisms involving prostate cancer racial disparity.

10. Genome-wide linkage scan of prostate cancer Gleason score and confirmation of chromosome 19q.