| Literature DB >> 14666380 |
G Damaj1, V Ivanov, B Le Brigand, E D'incan, M F Doglio, K Bilger, C Faucher, N Vey, J A Gastaut.
Abstract
A 57-year-old man with acute myeloid leukemia (AML) French-American-British (FAB) 4 developed disseminated invasive cerebral and pulmonary aspergillosis during postinduction aplasia. According to international consensus, infection was categorized as probable (two host factors: deep neutropenia for >10 days and refractory fever for >96 h; major clinical criteria of lower respiratory tract and CNS invasive fungal infection; positive results for galactomannan antigen in three blood samples). After the failure of standard amphotericin-based therapy, the spectacular regression of multifocal brain and lung lesions was rapidly achieved under a caspofungin acetate/voriconazole combination. Further permanent caspofungin maintenance with voriconazole added during aplasia periods permitted two consolidation courses and autograft-based intensification without any delay.Entities:
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Year: 2003 PMID： 14666380 DOI： 10.1007/s00277-003-0792-0
Source DB: PubMed Journal: Ann Hematol ISSN： 0939-5555 Impact factor: 3.673