Literature DB >> 14666249

Age-related changes of the multidrug resistance P-glycoprotein function in normal human peripheral blood T lymphocytes.

C G Machado1, R T Calado, A B Garcia, R P Falcão.   

Abstract

The multidrug resistance P-glycoprotein is a transmembrane efflux pump expressed by lymphocytes and is involved in their cytolytic activity. In the present study, we investigated the age-related changes of P-glycoprotein function in normal peripheral blood lymphocytes. Blood samples from 90 normal volunteers (age range, 0 to 86 years) were analyzed. P-glycoprotein function was assessed by the flow cytometric rhodamine 123 assay. P-glycoprotein function was highest in cord blood and progressively declined with age in peripheral blood T CD4+ and CD8+ cells. In contrast, P-glycoprotein function did not vary with age in CD19+ B or CD16+CD56+ natural killer cells. These data suggest that the decline in P-glycoprotein function in T CD4+ and CD8+ lymphocytes as a function of age may contribute to the decrease in T cell cytolytic activity with aging.

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Year:  2003        PMID： 14666249     DOI： 10.1590/s0100-879x2003001200006

Source DB:  PubMed          Journal:  Braz J Med Biol Res        ISSN： 0100-879X            Impact factor:   2.590


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