Literature DB >> 14665691

Increased phosphorylation of the neuronal L-type Ca(2+) channel Ca(v)1.2 during aging.

Monika A Davare1, Johannes W Hell.   

Abstract

An increase in Ca2+ influx through L-type Ca2+ channels is thought to contribute to neuronal dysfunctions that underlie senile symptoms and Alzheimer's disease. The molecular basis of the age-dependent up-regulation in neuronal L-type Ca2+ channel activity is largely unknown. We show that phosphorylation of the L-type channel Cav1.2 by cAMP-dependent protein kinase is increased >2-fold in the hippocampus of aged rats. The hippocampus is critical for learning and is one of the first brain regions to be affected in Alzheimer's disease. Phosphorylation of Cav1.2 by cAMP-dependent protein kinase strongly enhances its activity. Therefore, increased Cav1.2 phosphorylation may account for a substantial portion of the age-related rise in neuronal Ca2+ influx and its neuropathological consequences.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 14665691      PMCID： PMC307685          DOI： 10.1073/pnas.2236970100

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  86 in total

1.  Nomenclature of voltage-gated calcium channels.

Authors:  E A Ertel; K P Campbell; M M Harpold; F Hofmann; Y Mori; E Perez-Reyes; A Schwartz; T P Snutch; T Tanabe; L Birnbaumer; R W Tsien; W A Catterall
Journal:  Neuron       Date:  2000-03       Impact factor: 17.173

Review 2.  Ligand-gated ion channel interactions with cytoskeletal and signaling proteins.

Authors:  M Sheng; D T Pak
Journal:  Annu Rev Physiol       Date:  2000       Impact factor: 19.318

Review 3.  Structure and regulation of voltage-gated Ca2+ channels.

Authors:  W A Catterall
Journal:  Annu Rev Cell Dev Biol       Date:  2000       Impact factor: 13.827

4.  A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2.

Authors:  M A Davare; V Avdonin; D D Hall; E M Peden; A Burette; R J Weinberg; M C Horne; T Hoshi; J W Hell
Journal:  Science       Date:  2001-07-06       Impact factor: 47.728

5.  Functional role of L-type Cav1.3 Ca2+ channels in cardiac pacemaker activity.

Authors:  Matteo E Mangoni; Brigitte Couette; Emmanuel Bourinet; Josef Platzer; Daniel Reimer; Jörg Striessnig; Joël Nargeot
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-16       Impact factor: 11.205

Review 6.  Regulation of cardiac L-type calcium current by phosphorylation and G proteins.

Authors:  W Trautwein; J Hescheler
Journal:  Annu Rev Physiol       Date:  1990       Impact factor: 19.318

7.  Beta-adrenergic modulation of calcium channels in frog ventricular heart cells.

Authors:  B P Bean; M C Nowycky; R W Tsien
Journal:  Nature       Date:  1984 Jan 26-Feb 1       Impact factor: 49.962

8.  Neuronal Ca(V)1.3alpha(1) L-type channels activate at relatively hyperpolarized membrane potentials and are incompletely inhibited by dihydropyridines.

Authors:  W Xu; D Lipscombe
Journal:  J Neurosci       Date:  2001-08-15       Impact factor: 6.167

9.  Heterogeneity in the molecular composition of excitatory postsynaptic sites during development of hippocampal neurons in culture.

Authors:  A Rao; E Kim; M Sheng; A M Craig
Journal:  J Neurosci       Date:  1998-02-15       Impact factor: 6.167

10.  alpha 1D (Cav1.3) subunits can form l-type Ca2+ channels activating at negative voltages.

Authors:  A Koschak; D Reimer; I Huber; M Grabner; H Glossmann; J Engel; J Striessnig
Journal:  J Biol Chem       Date:  2001-04-02       Impact factor: 5.157
View more
  60 in total

1.  Reduction in neuronal L-type calcium channel activity in a double knock-in mouse model of Alzheimer's disease.

Authors:  Olivier Thibault; Tristano Pancani; Philip W Landfield; Christopher M Norris
Journal:  Biochim Biophys Acta       Date:  2012-01-10

2.  Ca(2+) channel currents of cortical neurons from pure and mixed cultures.

Authors:  Chen Zhou; Aiying Yang; Zhen Chai
Journal:  Cytotechnology       Date:  2011-12-06       Impact factor: 2.058

3.  Edaravone ameliorates oxidative stress associated cholinergic dysfunction and limits apoptotic response following focal cerebral ischemia in rat.

Authors:  Ajmal Ahmad; Mohd Moshahid Khan; Hayate Javed; Syed Shadab Raza; Tauheed Ishrat; M Badruzzaman Khan; Mohammed M Safhi; Fakhrul Islam
Journal:  Mol Cell Biochem       Date:  2012-05-22       Impact factor: 3.396

Review 4.  Phosphodiesterase inhibitors as therapeutics for traumatic brain injury.

Authors:  David J Titus; Anthony A Oliva; Nicole M Wilson; Coleen M Atkins
Journal:  Curr Pharm Des       Date:  2015       Impact factor: 3.116

5.  Age-dependent requirement of AKAP150-anchored PKA and GluR2-lacking AMPA receptors in LTP.

Authors:  Yuan Lu; Margaret Allen; Amy R Halt; Michael Weisenhaus; Robert F Dallapiazza; Duane D Hall; Yuriy M Usachev; G Stanley McKnight; Johannes W Hell
Journal:  EMBO J       Date:  2007-11-01       Impact factor: 11.598

Review 6.  Supramolecular assemblies and localized regulation of voltage-gated ion channels.

Authors:  Shuiping Dai; Duane D Hall; Johannes W Hell
Journal:  Physiol Rev       Date:  2009-04       Impact factor: 37.312

7.  α-Actinin-1 promotes activity of the L-type Ca2+ channel Cav 1.2.

Authors:  Matthew Turner; David E Anderson; Peter Bartels; Madeline Nieves-Cintron; Andrea M Coleman; Peter B Henderson; Kwun Nok Mimi Man; Pang-Yen Tseng; Vladimir Yarov-Yarovoy; Donald M Bers; Manuel F Navedo; Mary C Horne; James B Ames; Johannes W Hell
Journal:  EMBO J       Date:  2020-01-27       Impact factor: 11.598

8.  Hippocampal 'zipper' slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca(2+) channels with aging.

Authors:  Christopher M Norris; Eric M Blalock; Kuey-Chu Chen; Nada M Porter; Olivier Thibault; Susan D Kraner; Philip W Landfield
Journal:  Neurobiol Aging       Date:  2010-02       Impact factor: 4.673

9.  The slow afterhyperpolarization in hippocampal CA1 neurons covaries with spatial learning ability in aged Fisher 344 rats.

Authors:  Geoffrey C Tombaugh; Wayne B Rowe; Gregory M Rose
Journal:  J Neurosci       Date:  2005-03-09       Impact factor: 6.167

10.  Unchanged beta-adrenergic stimulation of cardiac L-type calcium channels in Ca v 1.2 phosphorylation site S1928A mutant mice.

Authors:  Toni Lemke; Andrea Welling; Carl Johannes Christel; Anne Blaich; Dominik Bernhard; Peter Lenhardt; Franz Hofmann; Sven Moosmang
Journal:  J Biol Chem       Date:  2008-09-30       Impact factor: 5.157
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.