Literature DB >> 146652

Metabolic and genetic control of isoenzyme spectrum of alkaline phosphatase in Escherichia coli.

M A Nesmeyanova, O B Marayeva, A I Severin, I S Kulayev.   

Abstract

Three proteins possessing alkaline phosphatase activity were detected in a fraction of periplasmic material of Escherichia coli K-10 and its mutants with constitutive synthesis of alkaline phosphatase. They also showed acid phosphatase, pyrophosphatase and ATPase activities. Through the use of phosphatase-negative mutants it was shown that these proteins were the products of a single structural gene and therefore represented alkaline phosphatase isozymes. The numbers of enzyme isoforms and possibly the spectrum of their phosphohydrolase activities were controlled by exogenous orthophosphate and depended on the integrity of regulator genes for alkaline phosphatase.

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Year:  1978        PMID： 146652     DOI： 10.1007/bf02876593

Source DB:  PubMed          Journal:  Folia Microbiol (Praha)        ISSN： 0015-5632            Impact factor:   2.099


  23 in total

1.  Effect of phosphate on multiple forms of Escherechia coli alkaline phosphatase.

Authors:  W F Bosron; B L Vallee
Journal:  Biochem Biophys Res Commun       Date:  1975-09-16       Impact factor: 3.575

2.  ISOLATION OF A PROTEIN SPECIFIED BY A REGULATOR GENE.

Authors:  A GAREN; N OTSUJI
Journal:  J Mol Biol       Date:  1964-06       Impact factor: 5.469

3.  DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS.

Authors:  B J DAVIS
Journal:  Ann N Y Acad Sci       Date:  1964-12-28       Impact factor: 5.691

4.  RELEASE OF ALKALINE PHOSPHATASE FROM CELLS OF ESCHERICHIA COLI UPON LYSOZYME SPHEROPLAST FORMATION.

Authors:  M H MALAMY; B L HORECKER
Journal:  Biochemistry       Date:  1964-12       Impact factor: 3.162

5.  A fine-structure genetic and chemical study of the enzyme alkaline phosphatase of E. coli. I. Purification and characterization of alkaline phosphatase.

Authors:  A GAREN; C LEVINTHAL
Journal:  Biochim Biophys Acta       Date:  1960-03-11

6.  [Effect of detergents and proteolytic enzymes on membrane-bound phosphohydrolases in Escherichia coli cells with repressed and depressed biosynthesis of these enzymes].

Authors:  M A Nesmeianova; O B Maraeva; A I Severin; E I Zaichkin; L S Kulaev
Journal:  Biokhimiia       Date:  1976

7.  Kinetics of substrate hydrolysis by molecular variants of Escherichia coli alkaline phosphatase.

Authors:  W Bloch; M J Schlesinger
Journal:  J Biol Chem       Date:  1974-03-25       Impact factor: 5.157

8.  The effect of calcium ions on the ATPase activity of pig kidney alkaline phosphatase.

Authors:  M Wass; P J Butterworth
Journal:  Biochim Biophys Acta       Date:  1972-12-01

9.  Pleiotropic effects of mutations involved in the regulation of Escherichia coli K-12 alkaline phosphatase.

Authors:  H Morris; M J Schlesinger; M Bracha; E Yagil
Journal:  J Bacteriol       Date:  1974-08       Impact factor: 3.490

10.  Changes in the membrane bound alkaline phosphatase of glucose and lactate grown vegetative cells of Bacillus subtilis SB15.

Authors:  A Ghosh; B K Ghosh
Journal:  Biochem Biophys Res Commun       Date:  1972-11-15       Impact factor: 3.575
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