Literature DB >> 14664923

No replication of the association between the Nicastrin gene and familial early-onset Alzheimer's disease.

Emmanuelle Cousin1, Didier Hannequin, Sandrine Macé, Bruno Dubois, Sylvain Ricard, Emmanuelle Génin, Christophe Brun, Céline Chansac, Laurent Pradier, Thierry Frebourg, Alexis Brice, Dominique Campion, Jean-François Deleuze.   

Abstract

Polymorphisms in the Nicastrin (NCSTN) gene have recently been associated with familial early-onset Alzheimer's disease (AD). The authors genotyped four NCTSN polymorphisms in a large cohort of 489 AD cases (including 158 sporadic early-onset AD cases and 95 familial early-onset AD cases) and 386 controls but failed to replicate the association between NCSTN haplotype B and AD.

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Year:  2003        PMID: 14664923     DOI: 10.1016/s0304-3940(03)01105-4

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN: 0304-3940            Impact factor:   3.046


  3 in total

1.  PEN-2 gene mutation in a familial Alzheimer's disease case.

Authors:  C Sala Frigerio; P Piscopo; E Calabrese; A Crestini; L Malvezzi Campeggi; R Civita di Fava; S Fogliarino; D Albani; G Marcon; R Cherchi; R Piras; G Forloni; A Confaloni
Journal:  J Neurol       Date:  2005-03-16       Impact factor: 4.849

2.  Deep sequencing of the Nicastrin gene in pooled DNA, the identification of genetic variants that affect risk of Alzheimer's disease.

Authors:  Michelle K Lupton; Petroula Proitsi; Makrina Danillidou; Magda Tsolaki; Gillian Hamilton; Richard Wroe; Megan Pritchard; Kathryn Lord; Belinda M Martin; Iwona Kloszewska; Hilkka Soininen; Patrizia Mecocci; Bruno Vellas; Denise Harold; Paul Hollingworth; Simon Lovestone; John F Powell
Journal:  PLoS One       Date:  2011-02-25       Impact factor: 3.240

3.  Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus.

Authors:  Gillian Hamilton; Richard Killick; Jean-Charles Lambert; Philippe Amouyel; Minerva M Carrasquillo; V Shane Pankratz; Neill R Graff-Radford; Dennis W Dickson; Ronald C Petersen; Steven G Younkin; John F Powell; Richard Wade-Martins
Journal:  Neurobiol Aging       Date:  2012-03-08       Impact factor: 4.673

  3 in total

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