Márcia R Amorim1, Eduardo E Castilla, Iêda M Orioli. 1. ECLAMC at Departamento de Genética, Universidade Federal do Rio de Janeiro, Caixa Postal 68 011, 21944-970, Rio de Janeiro, Brazil.
Abstract
OBJECTIVE: To verify whether Down's syndrome and neural tube defects arise more often in the same family than expected by chance. DESIGN: Population and familial survey. SETTING: Network of maternity hospitals in the Latin American collaborative study of congenital malformations (ECLAMC) in Argentina, Bolivia, Brazil, Chile, Colombia, Ecuador, Paraguay, Peru, Uruguay, and Venezuela between 1982 and 2000. PROBANDS: 2421 cases of neural tube defects, 952 of hydrocephalus, and 3095 of Down's syndrome registered from a total of 1 583 838 live births and stillbirths. MAIN OUTCOME MEASURES: Observed number of cases of Down's syndrome among siblings of probands with a neural tube defect or hydrocephalus and number expected on the basis of maternal age; observed number of cases of neural tube defects or hydrocephalus among siblings of probands with Down's syndrome and number expected according to the prevalence in the same population. RESULTS: Five cases of Down's syndrome occurred among 5404 pregnancies previous to a case of neural tube defect or hydrocephalus, compared with 5.13 expected after adjustment by maternal age. Twelve cases of neural tube defect or hydrocephalus occurred among 8066 pregnancies previous to a case of Down's syndrome, compared with 17.18 expected on the basis of the birth prevalence for neural tube defects plus hydrocephalus in the same population. CONCLUSION: No association occurred between families at risk of neural tube defects and those at risk of Down's syndrome.
OBJECTIVE: To verify whether Down's syndrome and neural tube defects arise more often in the same family than expected by chance. DESIGN: Population and familial survey. SETTING: Network of maternity hospitals in the Latin American collaborative study of congenital malformations (ECLAMC) in Argentina, Bolivia, Brazil, Chile, Colombia, Ecuador, Paraguay, Peru, Uruguay, and Venezuela between 1982 and 2000. PROBANDS: 2421 cases of neural tube defects, 952 of hydrocephalus, and 3095 of Down's syndrome registered from a total of 1 583 838 live births and stillbirths. MAIN OUTCOME MEASURES: Observed number of cases of Down's syndrome among siblings of probands with a neural tube defect or hydrocephalus and number expected on the basis of maternal age; observed number of cases of neural tube defects or hydrocephalus among siblings of probands with Down's syndrome and number expected according to the prevalence in the same population. RESULTS: Five cases of Down's syndrome occurred among 5404 pregnancies previous to a case of neural tube defect or hydrocephalus, compared with 5.13 expected after adjustment by maternal age. Twelve cases of neural tube defect or hydrocephalus occurred among 8066 pregnancies previous to a case of Down's syndrome, compared with 17.18 expected on the basis of the birth prevalence for neural tube defects plus hydrocephalus in the same population. CONCLUSION: No association occurred between families at risk of neural tube defects and those at risk of Down's syndrome.
Authors: C A Hobbs; S L Sherman; P Yi; S E Hopkins; C P Torfs; R J Hine; M Pogribna; R Rozen; S J James Journal: Am J Hum Genet Date: 2000-08-07 Impact factor: 11.025
Authors: T J Hassold; L C Burrage; E R Chan; L M Judis; S Schwartz; S J James; P A Jacobs; N S Thomas Journal: Am J Hum Genet Date: 2001-07-05 Impact factor: 11.025
Authors: Valerie B O'Leary; Anne Parle-McDermott; Anne M Molloy; Peadar N Kirke; Zachary Johnson; Mary Conley; John M Scott; James L Mills Journal: Am J Med Genet Date: 2002-01-15
Authors: Bernadette Chadefaux-Vekemans; Marie Coudé; François Muller; Jean François Oury; Allel Chabli; Jean Jaïs; Pierre Kamoun Journal: Pediatr Res Date: 2002-06 Impact factor: 3.756
Authors: L I Al-Gazali; R Padmanabhan; S Melnyk; P Yi; I P Pogribny; M Pogribna; M Bakir; Z A Hamid; Y Abdulrazzaq; A Dawodu; S J James Journal: Am J Med Genet Date: 2001-10-01