Literature DB >> 14661858

Cytotoxic effects of sesquiterpene lactones from the flowers of Hemisteptia lyrata B.

Tae Joung Ha1, Dae Sik Jang, Jong Rok Lee, Kyung Dong Lee, Jun Lee, Seon Woo Hwang, Hwa Jin Jung, Sang Hae Nam, Ki Hun Park, Min Suk Yang.   

Abstract

Four guaia-12,6-olide type sesquiterpene lactones, aguerin B (1), 8alpha-acetoxyzaluzanin C (2), cynaropicrin (3), and deacylcynaropicrin (4), were isolated from the flowers of Hemisteptia lyrata Bunge. It is the first report on the isolation of compounds 1-4 from Hemisteptia species. All the isolates (1-4) were examined for their cytotoxic activity against SK-OV-3, LOX-IMVI, A549, MCF-7, PC-3, and HCT-15 human cancer cell lines.

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Year:  2003        PMID： 14661858     DOI： 10.1007/bf02980201

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  7 in total

1.  Activities of psilostachyin A and cynaropicrin against Trypanosoma cruzi in vitro and in vivo.

Authors:  Cristiane França da Silva; Denise da Gama Jaen Batista; Julianna Siciliano De Araújo; Marcos Meuser Batista; Jessica Lionel; Elen Mello de Souza; Erica Ripoll Hammer; Patricia Bernardino da Silva; Maria De Mieri; Michael Adams; Stefanie Zimmermann; Matthias Hamburger; Reto Brun; Wolfgang Schühly; Maria de Nazaré Correia Soeiro
Journal:  Antimicrob Agents Chemother       Date:  2013-08-12       Impact factor: 5.191

Review 2.  Cynaropicrin: A Comprehensive Research Review and Therapeutic Potential As an Anti-Hepatitis C Virus Agent.

Authors:  Mahmoud F Elsebai; Andrei Mocan; Atanas G Atanasov
Journal:  Front Pharmacol       Date:  2016-12-08       Impact factor: 5.810

3.  Antiproliferative Effects of Cynara cardunculus L. var. altilis (DC) Lipophilic Extracts.

Authors:  Patrícia A B Ramos; Ângela R Guerra; Olinda Guerreiro; Sónia A O Santos; Helena Oliveira; Carmen S R Freire; Armando J D Silvestre; Maria F Duarte
Journal:  Int J Mol Sci       Date:  2016-12-29       Impact factor: 5.923

4.  In-vitro Bioactivity and Phytochemical Screening of Extracts from Rhizomes of Eremostachys azerbaijanica rech. f. Growing in Iran.

Authors:  Solmaz Asnaashari; Abbas Delazar; Parina Asgharian; Farzaneh Lotfipour; Sedigeh Bamdad Moghaddam; Fariba Heshmati Afshar
Journal:  Iran J Pharm Res       Date:  2017       Impact factor: 1.696

5.  Sesquiterpene Lactones and Flavonoids from Psephellus pyrrhoblepharus with Antiproliferative Activity on Human Gynecological Cancer Cell Lines.

Authors:  Pelin Tastan; Zsuzsanna Hajdú; Norbert Kúsz; István Zupkó; Izabella Sinka; Bijen Kivcak; Judit Hohmann
Journal:  Molecules       Date:  2019-08-30       Impact factor: 4.411

6.  The Sesquiterpene Lactone Cynaropicrin Manifests Strong Cytotoxicity in Glioblastoma Cells U-87 MG by Induction of Oxidative Stress.

Authors:  Rossella Rotondo; Maria Antonietta Oliva; Antonietta Arcella
Journal:  Biomedicines       Date:  2022-07-02

7.  Hemistepsin A Inhibits Cell Proliferation and Induces G0/G1-Phase Arrest, Cellular Senescence and Apoptosis Via the AMPK and p53/p21 Signals in Human Hepatocellular Carcinoma.

Authors:  Su Youn Baek; Ui Wook Hwang; Ho Young Suk; Young Woo Kim
Journal:  Biomolecules       Date:  2020-05-04
  7 in total

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