Literature DB >> 14661028

Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells.

Jonathan S Draper1, Kath Smith, Paul Gokhale, Harry D Moore, Edna Maltby, Julie Johnson, Lorraine Meisner, Thomas P Zwaka, James A Thomson, Peter W Andrews.   

Abstract

We have observed karyotypic changes involving the gain of chromosome 17q in three independent human embryonic stem (hES) cell lines on five independent occasions. A gain of chromosome 12 was seen occasionally. This implies that increased dosage of chromosome 17q and 12 gene(s) provides a selective advantage for the propagation of undifferentiated hES cells. These observations are instructive for the future application of hES cells in transplantation therapies in which the use of aneuploid cells could be detrimental.

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Year:  2003        PMID： 14661028     DOI： 10.1038/nbt922

Source DB:  PubMed          Journal:  Nat Biotechnol        ISSN： 1087-0156            Impact factor:   54.908


  279 in total

1.  The human embryonic stem cell proteome revealed by multidimensional fractionation followed by tandem mass spectrometry.

Authors:  Peng Zhao; Thomas C Schulz; Eric S Sherrer; D Brent Weatherly; Allan J Robins; Lance Wells
Journal:  Proteomics       Date:  2014-12-17       Impact factor: 3.984

2.  Genetic instability in neural stem cells: an inconvenient truth?

Authors:  Neil J Harrison
Journal:  J Clin Invest       Date:  2012-01-24       Impact factor: 14.808

3.  Clonal neural stem cells from human embryonic stem cell colonies.

Authors:  Radha Chaddah; Margot Arntfield; Susan Runciman; Laura Clarke; Derek van der Kooy
Journal:  J Neurosci       Date:  2012-06-06       Impact factor: 6.167

4.  Quality of Cell Products: Authenticity, Identity, Genomic Stability and Status of Differentiation.

Authors:  Kurt E J Dittmar; Meike Simann; Nadia Zghoul; Oliver Schön; Wilhelm Meyring; Horst Hannig; Lars Macke; Wilhelm G Dirks; Konstantin Miller; Henk S P Garritsen; Werner Lindenmaier
Journal:  Transfus Med Hemother       Date:  2010-03-08       Impact factor: 3.747

5.  High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity.

Authors:  Elisa Närvä; Reija Autio; Nelly Rahkonen; Lingjia Kong; Neil Harrison; Danny Kitsberg; Lodovica Borghese; Joseph Itskovitz-Eldor; Omid Rasool; Petr Dvorak; Outi Hovatta; Timo Otonkoski; Timo Tuuri; Wei Cui; Oliver Brüstle; Duncan Baker; Edna Maltby; Harry D Moore; Nissim Benvenisty; Peter W Andrews; Olli Yli-Harja; Riitta Lahesmaa
Journal:  Nat Biotechnol       Date:  2010-03-28       Impact factor: 54.908

6.  Differences between karyotypically normal and abnormal human embryonic stem cells.

Authors:  S Yang; G Lin; Y-Q Tan; L-Y Deng; D Yuan; G-X Lu
Journal:  Cell Prolif       Date:  2010-06       Impact factor: 6.831

7.  Timed inhibition of p38MAPK directs accelerated differentiation of human embryonic stem cells into cardiomyocytes.

Authors:  Meenakshi Gaur; Carissa Ritner; Rich Sievers; Anissa Pedersen; Megha Prasad; Harold S Bernstein; Yerem Yeghiazarians
Journal:  Cytotherapy       Date:  2010-10       Impact factor: 5.414

Review 8.  Induced pluripotency: history, mechanisms, and applications.

Authors:  Matthias Stadtfeld; Konrad Hochedlinger
Journal:  Genes Dev       Date:  2010-10-15       Impact factor: 11.361

9.  Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling.

Authors:  Linlin Wang; Thomas C Schulz; Eric S Sherrer; Derek S Dauphin; Soojung Shin; Angelique M Nelson; Carol B Ware; Mei Zhan; Chao-Zhong Song; Xiaoji Chen; Sandii N Brimble; Amanda McLean; Maria J Galeano; Elizabeth W Uhl; Kevin A D'Amour; Jonathan D Chesnut; Mahendra S Rao; C Anthony Blau; Allan J Robins
Journal:  Blood       Date:  2007-08-29       Impact factor: 22.113

Review 10.  The stem cell identity of testicular cancer.

Authors:  Amander T Clark
Journal:  Stem Cell Rev       Date:  2007-01       Impact factor: 5.739
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