Literature DB >> 14660021

Basal and feeding-evoked dopamine release in the rat nucleus accumbens is depressed by leptin.

Ute Krügel1, Thomas Schraft, Holger Kittner, Wieland Kiess, Peter Illes.   

Abstract

The involvement of the satiety-controlling hormone leptin in the modulation of the reward-associated dopamine release was investigated by monitoring the extracellular dopamine concentration in microdialysates from the nucleus accumbens of rats during feeding after infusion of leptin or artificial cerebrospinal fluid into the lateral ventricle of rats. Leptin suppressed the basal as well as the feeding-evoked extracellular dopamine concentration and reduced the amount and duration of food intake compared to the pair-feed vehicle-treated controls. These results suggest that leptin is involved in the dopaminergic modulation of feeding-induced rewarding functions.

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Year:  2003        PMID： 14660021     DOI： 10.1016/j.ejphar.2003.09.047

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  64 in total

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