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Literature DB >> 14660008

Proopiomelanocortin and melanocortin receptors in the adult rat retino-tectal system and their regulation after optic nerve transection.

Niclas Lindqvist¹, Ulla Näpänkangas, Jonas Lindblom, Finn Hallböök.

Abstract

The aim of this study was to characterise the expression of the melanocortin system in the normal and injured rat visual system. Using real-time polymerase chain reaction and immunohistochemistry, we detected melanocortin MC(3), MC(4) and MC(5) receptors and proopiomelanocortin in adult retina and superior colliculus. Melanocortin MC(4) receptor mRNA was the most abundant receptor. Melanocortin MC(3), MC(4) and MC(5) receptors were localised to the ganglion cell and inner nuclear layers and the melanocortin MC(3) and MC(4) receptors were localised to retinal ganglion cells. Transection of the optic nerve leads to ganglion cell death and both melanocortin receptor and proopiomelanocortin expression decreased in superior colliculus after transection whereas the expression was unchanged or even increased in the retina. alpha-Melanocyte-stimulating hormone elicited neurite outgrowth from embryonic retinal explants. Together, these data implicate a role for the melanocortin system in the adult rat retina and that melanocortins can stimulate neurite growth from retinal neurons.

Entities: Chemical Disease Gene Species

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Year: 2003 PMID： 14660008 DOI： 10.1016/j.ejphar.2003.10.011

Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432

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Cited

9 in total

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Proopiomelanocortin and melanocortin receptors in the adult rat retino-tectal system and their regulation after optic nerve transection.

Review 1. Extrapituitary production of anterior pituitary hormones: an overview.

Review 2. Applications of the role of α-MSH in ocular immune privilege.

3. Expression of molecular equivalent of hypothalamic-pituitary-adrenal axis in adult retinal pigment epithelium.

4. Endogenous melanocortin system activity contributes to the elevated arterial pressure in spontaneously hypertensive rats.

Review 5. Re-evaluating the treatment of acute optic neuritis.

6. Melanocortin receptor agonists MCR_1-5 protect photoreceptors from high-glucose damage and restore antioxidant enzymes in primary retinal cell culture.

Review 7. I'll take the low road: the evolutionary underpinnings of visually triggered fear.

8. Activation of Melanocortin Receptors MC 1 and MC 5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy.

9. Treatment of Noninfectious Retinal Vasculitis Using Subcutaneous Repository Corticotropin Injection.

Proopiomelanocortin and melanocortin receptors in the adult rat retino-tectal system and their regulation after optic nerve transection.

Review 1. Extrapituitary production of anterior pituitary hormones: an overview.

Review 2. Applications of the role of α-MSH in ocular immune privilege.

3. Expression of molecular equivalent of hypothalamic-pituitary-adrenal axis in adult retinal pigment epithelium.

4. Endogenous melanocortin system activity contributes to the elevated arterial pressure in spontaneously hypertensive rats.

Review 5. Re-evaluating the treatment of acute optic neuritis.

6. Melanocortin receptor agonists MCR1-5 protect photoreceptors from high-glucose damage and restore antioxidant enzymes in primary retinal cell culture.

Review 7. I'll take the low road: the evolutionary underpinnings of visually triggered fear.

8. Activation of Melanocortin Receptors MC 1 and MC 5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy.

9. Treatment of Noninfectious Retinal Vasculitis Using Subcutaneous Repository Corticotropin Injection.

6. Melanocortin receptor agonists MCR_1-5 protect photoreceptors from high-glucose damage and restore antioxidant enzymes in primary retinal cell culture.