BACKGROUND: Multi-slice detector computed tomography (MDCT) not only allows for the determination of coronary calcifications, but also for the noninvasive visualization of noncalcified plaques. Thus, coronary artery disease (CAD) can be detected at a fairly early stage. Since data on the prevalence of potentially rupture prone noncalcified coronary lesions are still missing, it was aim of the present investigation to study this in patients with a distinct cardiovascular risk profile, but without known CAD. METHODS: 68 patients with clinical suspicion of CAD and multiple cardiovascular risk factors were included in this prospective study. Calcium scoring, as well as the detection of noncalcified plaques were performed using a Somatom VZ scanner (Siemens, Forchheim, Germany). RESULTS: Calcium scoring could be performed in all patients on native scans; 63/68 (96%) of contrast enhanced scans showed sufficient image quality to perform a screening for noncalcified plaques. The three scans without diagnostic image quality had been performed at heart rates of 95 +/- 18/min. Coronary calcifications were found in 36/65 (55%) patients (Agatston score: 247 +/- 358). Additional noncalcified plaques were detected in 16/36 (45%) of these patients; 29/65 (45%) patients had no coronary calcifications (Agatston score: 0), but noncalcified plaques could be detected in 3/29 (10%) of these patients. CONCLUSIONS: The prevalence of noncalcified plaques was 29% in the whole study group, and even in 10% of patients without coronary calcifications. Further prospective large scale studies are required to confirm these data, and to evaluate the clinical implication of this finding.
BACKGROUND: Multi-slice detector computed tomography (MDCT) not only allows for the determination of coronary calcifications, but also for the noninvasive visualization of noncalcified plaques. Thus, coronary artery disease (CAD) can be detected at a fairly early stage. Since data on the prevalence of potentially rupture prone noncalcified coronary lesions are still missing, it was aim of the present investigation to study this in patients with a distinct cardiovascular risk profile, but without known CAD. METHODS: 68 patients with clinical suspicion of CAD and multiple cardiovascular risk factors were included in this prospective study. Calcium scoring, as well as the detection of noncalcified plaques were performed using a Somatom VZ scanner (Siemens, Forchheim, Germany). RESULTS:Calcium scoring could be performed in all patients on native scans; 63/68 (96%) of contrast enhanced scans showed sufficient image quality to perform a screening for noncalcified plaques. The three scans without diagnostic image quality had been performed at heart rates of 95 +/- 18/min. Coronary calcifications were found in 36/65 (55%) patients (Agatston score: 247 +/- 358). Additional noncalcified plaques were detected in 16/36 (45%) of these patients; 29/65 (45%) patients had no coronary calcifications (Agatston score: 0), but noncalcified plaques could be detected in 3/29 (10%) of these patients. CONCLUSIONS: The prevalence of noncalcified plaques was 29% in the whole study group, and even in 10% of patients without coronary calcifications. Further prospective large scale studies are required to confirm these data, and to evaluate the clinical implication of this finding.
Authors: Alexander W Leber; Andreas Knez; Alexander Becker; Christoph Becker; Maximilian Reiser; Gerhard Steinbeck; Peter Boekstegers Journal: Int J Cardiovasc Imaging Date: 2005-02 Impact factor: 2.357
Authors: Zahi A Fayad; Marc Sirol; Konstantin Nikolaou; Robin P Choudhury; Valentin Fuster Journal: Curr Atheroscler Rep Date: 2004-05 Impact factor: 5.113
Authors: S Schroeder; A Kuettner; T Wojak; J Janzen; M Heuschmid; T Athanasiou; T Beck; C Burgstahler; C Herdeg; C D Claussen; A F Kopp Journal: Heart Date: 2004-12 Impact factor: 5.994
Authors: Andreas F Kopp; Axel Küttner; Tobias Trabold; Martin Heuschmid; Stephen Schröder; C D Claussen Journal: Eur Radiol Date: 2003-12 Impact factor: 7.034