Konstantin Muranov1, Nicolas Poliansky2, Rudolf Winkler3, Gebhard Rieger3, Otto Schmut4, Jutta Horwath-Winter4. 1. Emanuel Institute of Biochemical Physics RAS, Kosygin Street 4, 117344, Moscow, Russia. k.muranov@sky.chph.ras.ru. 2. Emanuel Institute of Biochemical Physics RAS, Kosygin Street 4, 117344, Moscow, Russia. 3. Paracelsus Society for Balneology and Iodine Research, Bad Hall, Austria. 4. University Eye Hospital, Graz, Austria.
Abstract
BACKGROUND: Iodide has been used empirically against different age-related eye diseases, including cataract. The purpose of the present study was to investigate the effect of iodide on selenite-induced cataract in rat lens. METHODS: Young white rats received subcutaneously sodium selenite (20 and 30 nmol/g b.w.) on day 13 post partum (p.p.). Cataract development was measured by expert estimation and image data analysis. Potassium iodide (1.5 nmol/g b.w.) was given (1-5 times) i.p. at different times with respect to the selenite administration. Lens opacification was analyzed in selenite, selenite-iodide, iodide and control groups on day 7 after selenite administration. RESULTS: Iodide showed a significant protective effect against selenite cataract when injected 2 days (2 times) before selenite injection, i.e., on days 11 and 12 p.p. No significant effects on lens opacity were found: (1) after only one iodide injection (on day 12 p.p.), (2) after an initial iodide administration 1 h before selenite and (3) after injections of iodide once a day for 5 consecutive days. The protective effect of iodide was the same (about 50%) for both selenite doses used. CONCLUSIONS: There is a time-dependent protective influence of iodide against selenite cataract development. It is supposed that the anticataract effect of iodide could be based on direct or indirect antioxidant mechanisms.
BACKGROUND:Iodide has been used empirically against different age-related eye diseases, including cataract. The purpose of the present study was to investigate the effect of iodide on selenite-induced cataract in rat lens. METHODS: Young white rats received subcutaneously sodium selenite (20 and 30 nmol/g b.w.) on day 13 post partum (p.p.). Cataract development was measured by expert estimation and image data analysis. Potassium iodide (1.5 nmol/g b.w.) was given (1-5 times) i.p. at different times with respect to the selenite administration. Lens opacification was analyzed in selenite, selenite-iodide, iodide and control groups on day 7 after selenite administration. RESULTS:Iodide showed a significant protective effect against selenitecataract when injected 2 days (2 times) before selenite injection, i.e., on days 11 and 12 p.p. No significant effects on lens opacity were found: (1) after only one iodide injection (on day 12 p.p.), (2) after an initial iodide administration 1 h before selenite and (3) after injections of iodide once a day for 5 consecutive days. The protective effect of iodide was the same (about 50%) for both selenite doses used. CONCLUSIONS: There is a time-dependent protective influence of iodide against selenitecataract development. It is supposed that the anticataract effect of iodide could be based on direct or indirect antioxidant mechanisms.
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