Literature DB >> 14657206

Functions of lipoprotein receptors in neurons.

Uwe Beffert1, Peggy C Stolt, Joachim Herz.   

Abstract

The LDL receptor (LDLR) family is comprised of several multifunctional cell surface proteins that bind and endocytose ligands with diverse biological functions. One ligand common to all LDLR family members is apolipoprotein E (apoE), a lipid transport protein that also plays a central role in the pathogenesis of neurodegeneration in Alzheimer's disease. This review discusses the role of apoE and its receptors in the central nervous system and, in particular, the signaling mechanisms by which two members of the LDLR gene family, apoE receptor-2 and VLDL receptor, control brain development, normal neuronal positioning, and neurotransmission in the adult brain.

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Year:  2003        PMID： 14657206     DOI： 10.1194/jlr.R300017-JLR200

Source DB:  PubMed          Journal:  J Lipid Res        ISSN： 0022-2275            Impact factor:   5.922


  50 in total

1.  SorLA in glia: shared subcellular distribution patterns with caveolin-1.

Authors:  Iris K Salgado; Melissa Serrano; José O García; Namyr A Martínez; Héctor M Maldonado; Carlos A Báez-Pagán; José A Lasalde-Dominicci; Walter I Silva
Journal:  Cell Mol Neurobiol       Date:  2011-11-30       Impact factor: 5.046

Review 2.  Apolipoprotein E-induced cell signaling in the vessel wall.

Authors:  David Y Hui
Journal:  Rev Endocr Metab Disord       Date:  2004-12       Impact factor: 6.514

Review 3.  The role of gonadotropins in Alzheimer's disease: potential neurodegenerative mechanisms.

Authors:  Anna M Barron; Giuseppe Verdile; Ralph N Martins
Journal:  Endocrine       Date:  2006-04       Impact factor: 3.633

Review 4.  Low-Density Lipoprotein Receptor-Related Proteins in Skeletal Development and Disease.

Authors:  Tao Yang; Bart O Williams
Journal:  Physiol Rev       Date:  2017-07-01       Impact factor: 37.312

5.  Association study of polymorphisms in LRP1, tau and 5-HTT genes and Alzheimer's disease in a sample of Colombian patients.

Authors:  D A Forero; G Arboleda; J J Yunis; R Pardo; H Arboleda
Journal:  J Neural Transm (Vienna)       Date:  2005-12-14       Impact factor: 3.575

6.  Low-density lipoprotein receptors regulate microglial inflammation through c-Jun N-terminal kinase.

Authors:  Ana Pocivavsek; Mark P Burns; G William Rebeck
Journal:  Glia       Date:  2009-03       Impact factor: 7.452

7.  ApoE is required for maintenance of the dentate gyrus neural progenitor pool.

Authors:  Cui-Ping Yang; Jennifer A Gilley; Gui Zhang; Steven G Kernie
Journal:  Development       Date:  2011-08-31       Impact factor: 6.868

8.  Association of ApoE and LRP mRNA levels with dementia and AD neuropathology.

Authors:  Afia Akram; James Schmeidler; Pavel Katsel; Patrick R Hof; Vahram Haroutunian
Journal:  Neurobiol Aging       Date:  2011-06-15       Impact factor: 4.673

9.  Ligand-induced homotypic and heterotypic clustering of apolipoprotein E receptor 2.

Authors:  Shailaja D Divekar; Teal C Burrell; Jennifer E Lee; Edwin J Weeber; G William Rebeck
Journal:  J Biol Chem       Date:  2014-04-22       Impact factor: 5.157

10.  Influence of brain-derived neurotrophic factor and apolipoprotein E genetic variants on hemispheric and lateral ventricular volume of young healthy adults.

Authors:  Christos Sidiropoulos; Kourosh Jafari-Khouzani; Hamid Soltanian-Zadeh; Panayiotis Mitsias; Panagiotis Alexopoulos; Tanja Richter-Schmidinger; Martin Reichel; Piotr Lewczuk; Arnd Doerfler; Johannes Kornhuber
Journal:  Acta Neuropsychiatr       Date:  2011-06       Impact factor: 3.403
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