| Literature DB >> 14656117 |
Rainer Schobert1, Ralf Stehle, Wolfgang Milius.
Abstract
3-Alkylidenedihydrofuran-2,4-diones 1 can be photooxygenated with O(2)/TBHP to hydroperoxides 3 which slowly decompose to diols 5. Stable endoperoxides 4 are best prepared by photooxygenation of 1 with 2 equiv of O(2) in the presence of CuSO(4) and p-TosOH following a nonradical mechanism. They are rapidly reduced by anhydrous FeBr(2) to give butenolide 9 indicating a potential antimalarial activity.Entities:
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Year: 2003 PMID： 14656117 DOI： 10.1021/jo030270a
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354