Literature DB >> 14656090

Structure-activity relationship studies of illudins: analogues possessing a spiro-cyclobutane ring.

Trevor C McMorris1, Qiang Cong, Michael J Kelner.   

Abstract

Bicyclic and tricyclic analogues of anticancer sesquiterpene illudin S have been synthesized. These contain a spiro-cyclobutane instead of spiro-cyclopropane structure. The cytotoxicity of the former is less than that of the corresponding cyclopropane-containing compounds.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 14656090     DOI： 10.1021/jo0346499

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  4 in total

1.  Genome of Diaporthe sp. provides insights into the potential inter-phylum transfer of a fungal sesquiterpenoid biosynthetic pathway.

Authors:  Jose Guedes de Sena Filho; Maureen B Quin; Daniel J Spakowicz; Jeffrey J Shaw; Kaury Kucera; Brian Dunican; Scott A Strobel; Claudia Schmidt-Dannert
Journal:  Fungal Biol       Date:  2016-04-12

2.  Enantioselective total synthesis of (-)-acylfulvene and (-)-irofulven.

Authors:  Dustin S Siegel; Grazia Piizzi; Giovanni Piersanti; Mohammad Movassaghi
Journal:  J Org Chem       Date:  2009-12-18       Impact factor: 4.354

3.  Diastereoselective Synthesis of Spirocyclopropanes under Mild Conditions via Formal [2 + 1] Cycloadditions Using 2,3-Dioxo-4-benzylidene-pyrrolidines.

Authors:  Yi Li; Qing-Zhu Li; Li Huang; Hong Liang; Kai-Chuan Yang; Hai-Jun Leng; Yue Liu; Xu-Dong Shen; Xiao-Jun Gou; Jun-Long Li
Journal:  Molecules       Date:  2017-02-22       Impact factor: 4.411

4.  Optimization of the production process for the anticancer lead compound illudin M: downstream processing.

Authors:  Lillibeth Chaverra-Muñoz; Theresa Briem; Stephan Hüttel
Journal:  Microb Cell Fact       Date:  2022-08-17       Impact factor: 6.352
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.