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Literature DB >> 14654799

Metabolic engineering for drug discovery and development.

Chaitan Khosla¹, Jay D Keasling.

Abstract

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Year: 2003 PMID： 14654799 DOI： 10.1038/nrd1256

Source DB: PubMed Journal: Nat Rev Drug Discov ISSN： 1474-1776 Impact factor: 84.694

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47 in total

1. Accessorizing natural products: adding to nature's toolbox.

Authors: Sherry S Lamb; Gerard D Wright
Journal: Proc Natl Acad Sci U S A Date: 2005-01-12 Impact factor: 11.205

Review 2. The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life.

Authors: Joris Beld; Eva C Sonnenschein; Christopher R Vickery; Joseph P Noel; Michael D Burkart
Journal: Nat Prod Rep Date: 2014-01 Impact factor: 13.423

3. Synthetic protein scaffolds provide modular control over metabolic flux.

Authors: John E Dueber; Gabriel C Wu; G Reza Malmirchegini; Tae Seok Moon; Christopher J Petzold; Adeeti V Ullal; Kristala L J Prather; Jay D Keasling
Journal: Nat Biotechnol Date: 2009-08-02 Impact factor: 54.908

4. Role of isopentenyl-diphosphate isomerase in heterologous cyanobacterial (Synechocystis) isoprene production.

Authors: Julie E Chaves; Paloma Rueda Romero; Henning Kirst; Anastasios Melis
Journal: Photosynth Res Date: 2016-07-13 Impact factor: 3.573

5. Simultaneous production and partitioning of heterologous polyketide and isoprenoid natural products in an Escherichia coli two-phase bioprocess.

Authors: Brett A Boghigian; Melissa Myint; Jiequn Wu; Blaine A Pfeifer
Journal: J Ind Microbiol Biotechnol Date: 2011-04-13 Impact factor: 3.346

6. Total synthesis of (+)-roxaticin via C-C bond forming transfer hydrogenation: a departure from stoichiometric chiral reagents, auxiliaries, and premetalated nucleophiles in polyketide construction.

Authors: Soo Bong Han; Abbas Hassan; In Su Kim; Michael J Krische
Journal: J Am Chem Soc Date: 2010-11-10 Impact factor: 15.419

Metabolic engineering for drug discovery and development.

1. Accessorizing natural products: adding to nature's toolbox.

Review 2. The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life.

3. Synthetic protein scaffolds provide modular control over metabolic flux.

4. Role of isopentenyl-diphosphate isomerase in heterologous cyanobacterial (Synechocystis) isoprene production.

5. Simultaneous production and partitioning of heterologous polyketide and isoprenoid natural products in an Escherichia coli two-phase bioprocess.

6. Total synthesis of (+)-roxaticin via C-C bond forming transfer hydrogenation: a departure from stoichiometric chiral reagents, auxiliaries, and premetalated nucleophiles in polyketide construction.

7. OptORF: Optimal metabolic and regulatory perturbations for metabolic engineering of microbial strains.

Review 8. Antiviral lead compounds from marine sponges.

9. Model-driven evaluation of the production potential for growth-coupled products of Escherichia coli.

10. Programming cells by multiplex genome engineering and accelerated evolution.