Literature DB >> 14654304

Opioid hyperalgesia and tolerance versus 5-HT1A receptor-mediated inverse tolerance.

Xiao-Jun Xu1, Francis Colpaert, Zsuzsanna Wiesenfeld-Hallin.   

Abstract

In addition to analgesia, opioids also produce paradoxical hyperalgesic effects following acute and chronic treatment. In this article, we review the occurrence of this hyperalgesia under several conditions, and discuss the potential mechanisms and clinical implications. We also review recent evidence that paradoxical analgesia and inverse tolerance induced by stimulation of 5-HT(1A) receptors, which is a mirror image of opioid-induced hyperalgesia and tolerance, might achieve clinically significant analgesia in chronic pain.

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Year:  2003        PMID： 14654304     DOI： 10.1016/j.tips.2003.10.005

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  9 in total

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Journal:  Psychopharmacology (Berl)       Date:  2011-12-03       Impact factor: 4.530

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Authors:  Aaron Juni; Minying Cai; Magda Stankova; Amanda R Waxman; Caroline Arout; Gad Klein; Albert Dahan; Victor J Hruby; Jeffrey S Mogil; Benjamin Kest
Journal:  Anesthesiology       Date:  2010-01       Impact factor: 7.892

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Journal:  Eur J Clin Pharmacol       Date:  2010-02-13       Impact factor: 2.953

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Authors:  Igor Reznikov; Dorit Pud; Elon Eisenberg
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Review 6.  Radiotracers for the Central Serotoninergic System.

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Journal:  Pharmaceuticals (Basel)       Date:  2022-05-03

7.  Non-Peptide Opioids Differ in Effects on Mu-Opioid (MOP) and Serotonin 1A (5-HT1A) Receptors Heterodimerization and Cellular Effectors (Ca2+, ERK1/2 and p38) Activation.

Authors:  Vlad Radoi; Gerd Jakobsson; Vinko Palada; Andrej Nikosjkov; Henrik Druid; Lars Terenius; Eva Kosek; Vladana Vukojević
Journal:  Molecules       Date:  2022-04-06       Impact factor: 4.411

8.  Immunology and homeopathy. 5. The rationale of the 'Simile'.

Authors:  Paolo Bellavite; Riccardo Ortolani; Francesco Pontarollo; Giuseppina Pitari; Anita Conforti
Journal:  Evid Based Complement Alternat Med       Date:  2007-02-05       Impact factor: 2.629

9.  Persistent Rheb-induced mTORC1 activation in spinal cord neurons induces hypersensitivity in neuropathic pain.

Authors:  Xiaqing Ma; Wenjie Du; Wenying Wang; Limin Luo; Min Huang; Haiyan Wang; Raozhou Lin; Zhongping Li; Haibo Shi; Tifei Yuan; Wei Jiang; Paul F Worley; Tao Xu
Journal:  Cell Death Dis       Date:  2020-09-12       Impact factor: 8.469
  9 in total

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