Zhan-gui Tang1, Ping Zou, Xiao-li Xie. 1. Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha 410078, China.
Abstract
OBJECTIVE: To determine the relationship between E-cadherin over-expression and progression in oral verrucous carcinoma. METHODS: Immunohistochemistry assay was performed on 12 cases of oral verrucous carcinoma (VC) and 20 cases of oral squamous epithelial cells carcinoma (SCC) using monoclonal antibody against E-cadherin gene protein. RESULTS: The E-cadherin positive expression in VC (83.3%) was significantly higher than that in the poorly differentiated SCC(37.5%; P < 0.05), but the negative expression of E-cadherin in VC was between the well differentiated squamous cell carcinoma and the poorly differentiated squamous cell carcinoma. CONCLUSION: E-cadherin over-expression plays an important role in oral verrucous carcinoma.
OBJECTIVE: To determine the relationship between E-cadherin over-expression and progression in oral verrucous carcinoma. METHODS: Immunohistochemistry assay was performed on 12 cases of oral verrucous carcinoma (VC) and 20 cases of oral squamous epithelial cells carcinoma (SCC) using monoclonal antibody against E-cadherin gene protein. RESULTS: The E-cadherin positive expression in VC (83.3%) was significantly higher than that in the poorly differentiated SCC(37.5%; P < 0.05), but the negative expression of E-cadherin in VC was between the well differentiated squamous cell carcinoma and the poorly differentiated squamous cell carcinoma. CONCLUSION:E-cadherin over-expression plays an important role in oral verrucous carcinoma.