Literature DB >> 14651841

The BRCA2-EMSY connection: implications for breast and ovarian tumorigenesis.

Daniel A Haber1.   

Abstract

In this issue, Hughes-Davies et al. describe a novel gene product, EMSY, which suppresses the transactivational activity of BRCA2. EMSY is located within an amplicon in sporadic breast and ovarian cancers, suggesting that its overexpression may mimic the effects of BRCA2 inactivation. The implications for BRCA2 function are discussed.

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Year:  2003        PMID： 14651841     DOI： 10.1016/s0092-8674(03)00933-4

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  7 in total

1.  BRCA1 and BRCA2 pathways and the risk of cancers other than breast or ovarian.

Authors:  Bernard Friedenson
Journal:  MedGenMed       Date:  2005-06-29

Review 2.  Genetics of eosinophilic esophagitis.

Authors:  L C Kottyan; M E Rothenberg
Journal:  Mucosal Immunol       Date:  2017-02-22       Impact factor: 7.313

3.  EMSY promoted the growth and migration of ovarian cancer cells.

Authors:  Xiaohong Zhao; Yan Zhou; Mingchao Nie; Saiqiong Xian; Huli Chen; Yingmei Wen; Linjing Zhang; Yumin Huang; Mingfa Chen; Shaosheng Wang
Journal:  Tumour Biol       Date:  2014-12-16

4.  Deletion of BRCA2 exon 27 causes defects in response to both stalled and collapsed replication forks.

Authors:  Tae Moon Kim; Mi Young Son; Sherry Dodds; Lingchuan Hu; Paul Hasty
Journal:  Mutat Res       Date:  2014-06-22       Impact factor: 2.433

5.  EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion.

Authors:  Antonio Marzio; Emma Kurz; Jennifer M Sahni; Giuseppe Di Feo; Joseph Puccini; Shaowen Jiang; Carolina Alcantara Hirsch; Arnaldo A Arbini; Warren L Wu; Harvey I Pass; Dafna Bar-Sagi; Thales Papagiannakopoulos; Michele Pagano
Journal:  Cell       Date:  2021-12-27       Impact factor: 41.582

6.  Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation.

Authors:  Shivani Garapaty; Chong-Feng Xu; Patrick Trojer; Muktar A Mahajan; Thomas A Neubert; Herbert H Samuels
Journal:  J Biol Chem       Date:  2009-01-08       Impact factor: 5.157

Review 7.  A comprehensive analysis of BRCA2 gene: focus on mechanistic aspects of its functions, spectrum of deleterious mutations, and therapeutic strategies targeting BRCA2-deficient tumors.

Authors:  Anjali Shailani; Raman Preet Kaur; Anjana Munshi
Journal:  Med Oncol       Date:  2018-01-31       Impact factor: 3.064
  7 in total

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