OBJECTIVE: To disclose a clinical and histopathological effect of local low-dose oestradiol treatment on the vagina. DESIGN: A randomised, double-blind trial. SETTING:Two gynaecological departments at University Hospitals. SUBJECTS:Forty-eight postmenopausal women scheduled for surgery because of genital prolapse. INTERVENTION: 25 micrograms oestradiol or placebo, administered as vaginal pessaries daily, 3 weeks prior to surgery. MAIN OUTCOME MEASURES: Cytological, histological and clinical changes of the vaginal mucosa. RESULTS: The thickness of the vaginal wall increased as did the oestrogenic index. No clinical effect was seen apart from decreased incidence of recurrent cystitis postoperatively. CONCLUSIONS: Preoperative oestrogen treatment has been shown to reduce the incidence of recurrent cystitis and may be needed for stimulation of vaginal mucosa; the short-term clinical effect is not convincing, however.
RCT Entities:
OBJECTIVE: To disclose a clinical and histopathological effect of local low-dose oestradiol treatment on the vagina. DESIGN: A randomised, double-blind trial. SETTING: Two gynaecological departments at University Hospitals. SUBJECTS: Forty-eight postmenopausal women scheduled for surgery because of genital prolapse. INTERVENTION: 25 micrograms oestradiol or placebo, administered as vaginal pessaries daily, 3 weeks prior to surgery. MAIN OUTCOME MEASURES: Cytological, histological and clinical changes of the vaginal mucosa. RESULTS: The thickness of the vaginal wall increased as did the oestrogenic index. No clinical effect was seen apart from decreased incidence of recurrent cystitis postoperatively. CONCLUSIONS: Preoperative oestrogen treatment has been shown to reduce the incidence of recurrent cystitis and may be needed for stimulation of vaginal mucosa; the short-term clinical effect is not convincing, however.
Authors: David D Rahn; Renée M Ward; Tatiana V Sanses; Cassandra Carberry; Mamta M Mamik; Kate V Meriwether; Cedric K Olivera; Husam Abed; Ethan M Balk; Miles Murphy Journal: Int Urogynecol J Date: 2014-11-13 Impact factor: 2.894
Authors: Nirk E Quispe Calla; Rodolfo D Vicetti Miguel; Kristen M Aceves; Huijie Huang; Brooke Howitt; Thomas L Cherpes Journal: Tissue Barriers Date: 2021-01-11
Authors: Ginger D Constantine; Shelli Graham; Kate Lapane; Kathleen Ohleth; Brian Bernick; James Liu; Sebastian Mirkin Journal: Menopause Date: 2019-07 Impact factor: 2.953
Authors: M-L Marschalek; K Bodner; O Kimberger; S Zehetmayer; R Morgenbesser; W Dietrich; C Obruca; H Husslein; W Umek; H Koelbl; B Bodner-Adler Journal: BJOG Date: 2021-09-21 Impact factor: 7.331
Authors: Natalia Schlabritz-Loutsevitch; Scott E Gygax; Edward Dick; William L Smith; Cathy Snider; Gene Hubbard; Gary Ventolini Journal: Sci Rep Date: 2016-05-26 Impact factor: 4.379