Literature DB >> 14649827

Production of vancomycin aglycone conjugated to a peptide carrier domain derived from a biosynthetic non-ribosomal peptide synthetase.

Francesca Vitali1, Katja Zerbe, John A Robinson.   

Abstract

A method for attaching the vancomycin aglycone to a peptide carrier domain (PCD) is reported which involves reacting the apo-PCD produced in Escherichia coli with vancomycin aglycone-coenzyme A thioester, catalyzed by the phosphopantetheinyl transferase Sfp from Bacillus subtilis.

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Year:  2003        PMID： 14649827     DOI： 10.1039/b308247d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

Review 1.  How nature morphs peptide scaffolds into antibiotics.

Authors:  Elizabeth M Nolan; Christopher T Walsh
Journal:  Chembiochem       Date:  2009-01-05       Impact factor: 3.164

2.  Synthesis of 4'-aminopantetheine and derivatives to probe aminoglycoside N-6'-acetyltransferase.

Authors:  Xuxu Yan; T Olukayode Akinnusi; Aaron T Larsen; Karine Auclair
Journal:  Org Biomol Chem       Date:  2011-01-12       Impact factor: 3.876

3.  Characterization of SafC, a catechol 4-O-methyltransferase involved in saframycin biosynthesis.

Authors:  James T Nelson; Jaeheon Lee; James W Sims; Eric W Schmidt
Journal:  Appl Environ Microbiol       Date:  2007-04-20       Impact factor: 4.792
  3 in total

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