OBJECTIVE: To study the liver-protection and promoting bile secretion of ursolic acid. METHODS: Ursolic acid was administrated to the mice with liver injury induced by CCl4 or APIT. ALT, AST levels in serum were examined. The bile flow rate and the concentration of the main components in the bile of rats administrated with ursolic acid were estimated. RESULTS: Ursolic acid could decrease the serum ALT, AST, SB levels in the mice treated with CCl4 or APIT, promote the secretion of bile and increase the concentration of bilirubin in the bile. CONCLUSION: Ursolic acid exhibited significant liver protection and promoting blie secretion.
OBJECTIVE: To study the liver-protection and promoting bile secretion of ursolic acid. METHODS: Ursolic acid was administrated to the mice with liver injury induced by CCl4 or APIT. ALT, AST levels in serum were examined. The bile flow rate and the concentration of the main components in the bile of rats administrated with ursolic acid were estimated. RESULTS: Ursolic acid could decrease the serum ALT, AST, SB levels in the mice treated with CCl4 or APIT, promote the secretion of bile and increase the concentration of bilirubin in the bile. CONCLUSION: Ursolic acid exhibited significant liver protection and promoting blie secretion.
Authors: M Anusha; M Venkateswarlu; V Prabhakaran; S Shareen Taj; B Pushpa Kumari; D Ranganayakulu Journal: Indian J Pharmacol Date: 2011-09 Impact factor: 1.200