| Literature DB >> 14648644 |
Liang Fang1, Sachihiko Numajiri, Daisuke Kobayashi, Hideo Ueda, Koji Nakayama, Hiroshi Miyamae, Yasunori Morimoto.
Abstract
The preparation of mefenamic acid (MH)-alkanolamine (propanolamine, diethanolamine, triethanolamine) complexes was attempted to increase the transdermal flux of MH. Differential scanning calorimetry, Fourier transform infrared spectroscopy, and X-ray crystallographic studies demonstrated that MH and each alkanolamine formed an ion pair complex. The series of amine complexes had a lower melting point and higher solubility in water compared with pure MH. Copyright 2004 Wiley-Liss, Inc.Mesh：
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Year: 2004 PMID： 14648644 DOI： 10.1002/jps.10468
Source DB: PubMed Journal: J Pharm Sci ISSN： 0022-3549 Impact factor: 3.534