Literature DB >> 14647914

[Cerebral vasospasms with hemodynamic infarctions as a complication of HELLP syndrome].

S Harscher1, O W Witte, U Möller, G Bloos, S O R Pfleiderer, C Terborg.   

Abstract

Sinal thrombosis, intracerebral bleeding, cerebral edema, and cerebral vasospasm are typical neurological complications in pre- and eclampsia. Hemolysis, elevated liver enzyme, and low platelet (HELLP) syndrome is a rare, severe complication of pre-eclampsia. We present the case of a 33-year-old woman with HELLP syndrome. After a cesarean section, generalized epileptic seizure occurred and intubation was necessary due to sustained unconsciousness. Despite magnesium therapy, bilateral hemodynamic ischemic infarctions and narrowing of the circle of Willis were visible on MRI, and vasospasm of all large basal cerebral arteries was confirmed by cerebral angiography and transcranial Doppler sonography. During the following 2 weeks, the cerebral vasospasm resolved with application of high-dose methyl prednisolone and nimodipine. After extubation, the patient initially suffered from mild psychosyndrome and ataxia but recovered completely after 3 months. The HELLP syndrome may be complicated by cerebral vasospasm with subsequent hemodynamic strokes. Combined treatment with magnesium, corticosteroids, and nimodipine can be recommended. In our case, this regimen led to resolution of the cerebral vasospasm and complete clinical recovery.

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Year:  2003        PMID: 14647914     DOI: 10.1007/s00115-003-1581-7

Source DB:  PubMed          Journal:  Nervenarzt        ISSN: 0028-2804            Impact factor:   1.214


  24 in total

1.  CT and angiographic correlation of severe neurological disease in toxemia of pregnancy.

Authors:  L K Lewis; D B Hinshaw; A D Will; A N Hasso; J R Thompson
Journal:  Neuroradiology       Date:  1988       Impact factor: 2.804

2.  Intracerebral hemorrhage and postpartum cerebral vasculopathy.

Authors:  Romergryko G Geocadin; Alexander Y Razumovsky; Robert J Wityk; Anish Bhardwaj; John A Ulatowski
Journal:  J Neurol Sci       Date:  2002-12-15       Impact factor: 3.181

3.  Cerebral vasoconstriction in toxemia.

Authors:  A D Will; K L Lewis; D B Hinshaw; K Jordan; L M Cousins; A N Hasso; J R Thompson
Journal:  Neurology       Date:  1987-09       Impact factor: 9.910

4.  Recurrent intracranial hemorrhage due to postpartum cerebral angiopathy: implications for management.

Authors:  M R Ursell; C L Marras; R Farb; D W Rowed; S E Black; J R Perry
Journal:  Stroke       Date:  1998-09       Impact factor: 7.914

5.  HELLP syndrome with haemaglobin vasospasm.

Authors:  J Gliemroth; U Knopp; U Kehler; R Felberbaum; G Nowak
Journal:  J Clin Neurosci       Date:  2000-01       Impact factor: 1.961

6.  Maternal morbidity and mortality in 442 pregnancies with hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome)

Authors:  B M Sibai; M K Ramadan; I Usta; M Salama; B M Mercer; S A Friedman
Journal:  Am J Obstet Gynecol       Date:  1993-10       Impact factor: 8.661

7.  Magnetic resonance imaging angiography in a case of eclampsia.

Authors:  N Kanayama; A Nakajima; K Maehara; A Halim; Y Kajiwara; H Isoda; T Masui; T Terao
Journal:  Gynecol Obstet Invest       Date:  1993       Impact factor: 2.031

8.  Syndrome of hemolysis, elevated liver enzymes, and low platelet count: a severe consequence of hypertension in pregnancy.

Authors:  L Weinstein
Journal:  Am J Obstet Gynecol       Date:  1982-01-15       Impact factor: 8.661

9.  Transcranial Doppler findings of cerebral vasospasm in preeclampsia.

Authors:  W F Hansen; S J Burnham; T O Svendsen; V L Katz; J M Thorp; A R Hansen
Journal:  J Matern Fetal Med       Date:  1996 Jul-Aug

Review 10.  Preeclampsia: pathophysiology, diagnosis, and management.

Authors:  M D Lindheimer; A I Katz
Journal:  Annu Rev Med       Date:  1989       Impact factor: 13.739

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