| Literature DB >> 14647531 |
Md Shah Amran1, Nobuo Homma, Keitaro Hashimoto.
Abstract
The Na+-Ca2+ exchange (NCX) system plays a pivotal role in regulating intracellular Ca2+ concentration in cardiomyocytes, neuronal cells, kidney and a variety of other cells. It performs a particularly important function in regulating cardiac contractility and electrical activity. One of the leading NCX inhibitors is KB-R9743 (KBR) that appears to exhibit selectivity for Ca2+-influx-mode NCX activity (reverse mode of NCX). In this article we reviewed pharmacology of KBR and provide a brief summary of studies with other NCX inhibitors, such as SEA0400 (SEA) and SN-6 (SN). Potential clinical usefulness of KBR and other NCX inhibitors is still controversial but the reviewed findings may be helpful in designing more selective and clinically useful NCX inhibitors for the treatment of cardiac, neuronal and kidney diseases.Entities:
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Year: 2003 PMID： 14647531 DOI： 10.1111/j.1527-3466.2003.tb00121.x
Source DB: PubMed Journal: Cardiovasc Drug Rev ISSN： 0897-5957