Literature DB >> 14647295

The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?

Dieter A Wolf1, Chunshui Zhou, Susan Wee.   

Abstract

The COP9 signalosome (CSN) is a highly conserved protein complex implicated in diverse biological functions that involve ubiquitin-mediated proteolysis. Paradoxically, conserved enzymatic activities associated with CSN inhibit cullin ubiquitin ligase activity in vitro, whereas mutational analysis suggests that CSN promotes cullin-dependent proteolysis in vivo. This apparent paradox can be resolved in a model that proposes CSN-mediated cullin inhibition is a prerequisite for the proper assembly and maintenance of active cullin ubiquitin ligase complexes.

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Year:  2003        PMID： 14647295     DOI： 10.1038/ncb1203-1029

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  97 in total

1.  Mapping the protein interaction network of the human COP9 signalosome complex using a label-free QTAX strategy.

Authors:  Lei Fang; Robyn M Kaake; Vishal R Patel; Yingying Yang; Pierre Baldi; Lan Huang
Journal:  Mol Cell Proteomics       Date:  2012-04-03       Impact factor: 5.911

2.  The COP9 signalosome: its regulation of cullin-based E3 ubiquitin ligases and role in photomorphogenesis.

Authors:  Cynthia D Nezames; Xing Wang Deng
Journal:  Plant Physiol       Date:  2012-06-19       Impact factor: 8.340

3.  The COP9 signalosome is required for light-dependent timeless degradation and Drosophila clock resetting.

Authors:  Alyson Knowles; Kyunghee Koh; June-Tai Wu; Cheng-Ting Chien; Daniel A Chamovitz; Justin Blau
Journal:  J Neurosci       Date:  2009-01-28       Impact factor: 6.167

Review 4.  Macrophage migration inhibitory factor manipulation and evaluation in tumoral hypoxic adaptation.

Authors:  Millicent Winner; Lin Leng; Wayne Zundel; Robert A Mitchell
Journal:  Methods Enzymol       Date:  2007       Impact factor: 1.600

5.  The Arabidopsis CSN5A and CSN5B subunits are present in distinct COP9 signalosome complexes, and mutations in their JAMM domains exhibit differential dominant negative effects on development.

Authors:  Giuliana Gusmaroli; Suhua Feng; Xing Wang Deng
Journal:  Plant Cell       Date:  2004-10-14       Impact factor: 11.277

6.  Jun activation domain-binding protein 1 (JAB1) is required for the optimal response to interferons.

Authors:  Ryuta Muromoto; Maiko Nakajima; Koki Hirashima; Toru Hirao; Shigeyuki Kon; Kazuya Shimoda; Kenji Oritani; Tadashi Matsuda
Journal:  J Biol Chem       Date:  2013-09-16       Impact factor: 5.157

7.  Distinct aerobic and hypoxic mechanisms of HIF-alpha regulation by CSN5.

Authors:  Lynne Bemis; Denise A Chan; Carla V Finkielstein; Lin Qi; Patrick D Sutphin; Xiaojiang Chen; Kurt Stenmark; Amato J Giaccia; Wayne Zundel
Journal:  Genes Dev       Date:  2004-04-01       Impact factor: 11.361

8.  COP9 signalosome complex subunit 5, an IFT20 binding partner, is essential to maintain male germ cell survival and acrosome biogenesis†.

Authors:  Qian Huang; Hong Liu; Jing Zeng; Wei Li; Shiyang Zhang; Ling Zhang; Shizhen Song; Ting Zhou; Miriam Sutovsky; Peter Sutovsky; Ruggero Pardi; Rex A Hess; Zhibing Zhang
Journal:  Biol Reprod       Date:  2020-02-12       Impact factor: 4.285

9.  COP9 signalosome- and 26S proteasome-dependent regulation of SCFTIR1 accumulation in Arabidopsis.

Authors:  Johannes Stuttmann; Esther Lechner; Raphael Guérois; Jane E Parker; Laurent Nussaume; Pascal Genschik; Laurent D Noël
Journal:  J Biol Chem       Date:  2009-01-15       Impact factor: 5.157

10.  Stable form of JAB1 enhances proliferation and maintenance of hematopoietic progenitors.

Authors:  Masaaki Mori; Noriko Yoneda-Kato; Akihiro Yoshida; Jun-ya Kato
Journal:  J Biol Chem       Date:  2008-07-30       Impact factor: 5.157
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