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Literature DB >> 14647237

Paradigm shift in neuroprotective drug development: clinically tolerated NMDA receptor inhibition by memantine.

S A Lipton, H-S V Chen.

Abstract

Entities: Chemical

Mesh：

Substances：

Year: 2004 PMID： 14647237 DOI： 10.1038/sj.cdd.4401344

Source DB: PubMed Journal: Cell Death Differ ISSN： 1350-9047 Impact factor: 15.828

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17 in total

1. Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses.

Authors: Peng Xia; Huei-sheng Vincent Chen; Dongxian Zhang; Stuart A Lipton
Journal: J Neurosci Date: 2010-08-18 Impact factor: 6.167

2. Effects of memantine on cerebrospinal fluid biomarkers of neurofibrillary pathology.

Authors: Lidia Glodzik; Susan De Santi; Kenneth E Rich; Miroslaw Brys; Elizabeth Pirraglia; Rachel Mistur; Remigiusz Switalski; Lisa Mosconi; Martin Sadowski; Henrik Zetterberg; Kaj Blennow; Mony J de Leon
Journal: J Alzheimers Dis Date: 2009 Impact factor: 4.472

3. Hypoxia enhances S-nitrosylation-mediated NMDA receptor inhibition via a thiol oxygen sensor motif.

Authors: Hiroto Takahashi; Yeonsook Shin; Seung-Je Cho; Wagner M Zago; Tomohiro Nakamura; Zezong Gu; Yuliang Ma; Hiroyasu Furukawa; Robert Liddington; Dongxian Zhang; Gary Tong; Huei-Sheng Vincent Chen; Stuart A Lipton
Journal: Neuron Date: 2007-01-04 Impact factor: 17.173

4. An Experimental Study to Evaluate the Effect of Memantine in Animal Models of Anxiety in Swiss Albino Mice.

Authors: Harish G Bagewadi; Afzal Khan Ak; Rekha M Shivaramegowda
Journal: J Clin Diagn Res Date: 2015-08-01

Review 5. Advances in neuroprotective strategies: potential therapies for intracerebral hemorrhage.

Authors: Brian Y Hwang; Geoffrey Appelboom; Amit Ayer; Christopher P Kellner; Ivan S Kotchetkov; Paul R Gigante; Raqeeb Haque; Michael Kellner; E Sander Connolly
Journal: Cerebrovasc Dis Date: 2010-12-21 Impact factor: 2.762

Review 6. Experimental and potential future therapeutic approaches for HIV-1 associated dementia targeting receptors for chemokines, glutamate and erythropoietin.

Authors: M Kaul; S A Lipton
Journal: Neurotox Res Date: 2005-10 Impact factor: 3.911

Paradigm shift in neuroprotective drug development: clinically tolerated NMDA receptor inhibition by memantine.

1. Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses.

2. Effects of memantine on cerebrospinal fluid biomarkers of neurofibrillary pathology.

3. Hypoxia enhances S-nitrosylation-mediated NMDA receptor inhibition via a thiol oxygen sensor motif.

4. An Experimental Study to Evaluate the Effect of Memantine in Animal Models of Anxiety in Swiss Albino Mice.

Review 5. Advances in neuroprotective strategies: potential therapies for intracerebral hemorrhage.

Review 6. Experimental and potential future therapeutic approaches for HIV-1 associated dementia targeting receptors for chemokines, glutamate and erythropoietin.

7. Comparison of cannabidiol, antioxidants, and diuretics in reversing binge ethanol-induced neurotoxicity.

8. Clinical trials for neuroprotective therapies in intracerebral hemorrhage: a new roadmap from bench to bedside.

9. Enhanced Hypothalamic NMDA Receptor Activity Contributes to Hyperactivity of HPA Axis in Chronic Stress in Male Rats.

10. Current therapeutic options for Alzheimer's disease.