| Literature DB >> 14647196 |
J D Kim1, B K Choi, J S Bae, U H Lee, I S Han, H W Lee, B S Youn, D S Vinay, B S Kwon.
Abstract
The gene encoding the natural ligand of murine glucocorticoid-induced tumor necrosis factor receptor (GITR) was cloned and characterized. The putative GITR ligand (GITRL) is composed of 173 amino acids with features resembling those of type II membrane proteins and is 51% identical to the human activation-inducible TNF receptor (AITR) ligand, TL6. Expression of the GITRL is restricted to immature and mature splenic dendritic cells. GITRL binds GITR expressed on HEK 293 cells and triggers NF-kappaB activation. Functional studies reveal that soluble CD8-GITRL prevents CD4+CD25+ regulatory T-cell-mediated suppressive activities.Entities:
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Year: 2003 PMID： 14647196 DOI： 10.1038/sj.gene.6364026
Source DB: PubMed Journal: Genes Immun ISSN： 1466-4879 Impact factor: 2.676