Literature DB >> 14646323

Urinary metabolites of nobiletin orally administered to rats.

Takaaki Yasuda1, Yukako Yoshimura, Hisako Yabuki, Takahiro Nakazawa, Keisuke Ohsawa, Yoshihiro Mimaki, Yutaka Sashida.   

Abstract

During the course of our systematic investigation of the metabolism of flavonoids, the polymethoxyflavone nobiletin, occurring in the fruits of Citrus depressa, was orally administered to rats. The urinary metabolites were separated and identified by three-dimensional HPLC equipped with a photodiode array detector and the structure was determined by spectroscopic methods to be 4'-hydroxy-3',5,6,7,8-pentamethoxyflavone (1).

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Year:  2003        PMID： 14646323     DOI： 10.1248/cpb.51.1426

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  8 in total

1.  Fermented Citrus reticulata (ponkan) fruit squeezed draff that contains a large amount of 4'-demethylnobiletin prevents MK801-induced memory impairment.

Authors:  Ichiro Kawahata; Tatsuya Suzuki; Evelyn Gutiérrez Rico; Shuichi Kusano; Hiroshi Tamura; Yoshihiro Mimaki; Tohru Yamakuni
Journal:  J Nat Med       Date:  2017-05-09       Impact factor: 2.343

2.  A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents.

Authors:  Kanokkarn Phromnoi; Simone Reuter; Bokyung Sung; Sahdeo Prasad; Ramaswamy Kannappan; Vivek R Yadav; Wisinee Chanmahasathien; Pornngarm Limtrakul; Bharat B Aggarwal
Journal:  Mol Pharmacol       Date:  2010-10-07       Impact factor: 4.436

3.  Use of silkworms for identification of drug candidates having appropriate pharmacokinetics from plant sources.

Authors:  Yukihiro Asami; Ryo Horie; Hiroshi Hamamoto; Kazuhisa Sekimizu
Journal:  BMC Pharmacol       Date:  2010-06-11

4.  Pharmacological actions of nobiletin in the modulation of platelet function.

Authors:  Sakthivel Vaiyapuri; Harvey Roweth; Marfoua S Ali; Amanda J Unsworth; Alexander R Stainer; Gagan D Flora; Marilena Crescente; Chris I Jones; Leonardo A Moraes; Jonathan M Gibbins
Journal:  Br J Pharmacol       Date:  2015-06-26       Impact factor: 8.739

Review 5.  Nobiletin in Cancer Therapy: How This Plant Derived-Natural Compound Targets Various Oncogene and Onco-Suppressor Pathways.

Authors:  Milad Ashrafizadeh; Ali Zarrabi; Sedigheh Saberifar; Farid Hashemi; Kiavash Hushmandi; Fardin Hashemi; Ebrahim Rahmani Moghadam; Reza Mohammadinejad; Masoud Najafi; Manoj Garg
Journal:  Biomedicines       Date:  2020-05-05

Review 6.  The Application of Citrus folium in Breast Cancer and the Mechanism of Its Main Component Nobiletin: A Systematic Review.

Authors:  Yuan Wu; Chien-Shan Cheng; Qiong Li; Jing-Xian Chen; Ling-Ling Lv; Jia-Yue Xu; Kai-Yuan Zhang; Lan Zheng
Journal:  Evid Based Complement Alternat Med       Date:  2021-06-29       Impact factor: 2.629

Review 7.  Anti-dementia Activity of Nobiletin, a Citrus Flavonoid: A Review of Animal Studies.

Authors:  Akira Nakajima; Yasushi Ohizumi; Kiyofumi Yamada
Journal:  Clin Psychopharmacol Neurosci       Date:  2014-08-12       Impact factor: 2.582

8.  Nobiletin Delays Aging and Enhances Stress Resistance of Caenorhabditis elegans.

Authors:  Xueyan Yang; Hong Wang; Tong Li; Ling Chen; Bisheng Zheng; Rui Hai Liu
Journal:  Int J Mol Sci       Date:  2020-01-04       Impact factor: 5.923
  8 in total

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