Literature DB >> 14645597

Detailed analysis of the CD8+ T-cell response following adenovirus vaccination.

Teng Chih Yang1, Kelley Dayball, Yong Hong Wan, Jonathan Bramson.   

Abstract

We examined CD8(+) T-cell expansion and function following intramuscular immunization with a recombinant adenovirus. This study has identified a number of properties which may explain the strong immunogenicity of adenovirus vectors: (i) the ability to deliver large amounts of antigen into the lymphoid tissues, (ii) the ability to induce rapid expansion and migration of CD8(+) T cells throughout the lymphatics, and (iii) the ability to produce a sustained, high-level CD8(+) T-cell response.

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Year:  2003        PMID: 14645597      PMCID: PMC296052          DOI: 10.1128/jvi.77.24.13407-13411.2003

Source DB:  PubMed          Journal:  J Virol        ISSN: 0022-538X            Impact factor:   5.103


  22 in total

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10.  Evaluation of a Fiber-Modified Adenovirus Vector Vaccine against Foot-and-Mouth Disease in Cattle.

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