| Literature DB >> 14645597 |
Teng Chih Yang1, Kelley Dayball, Yong Hong Wan, Jonathan Bramson.
Abstract
We examined CD8(+) T-cell expansion and function following intramuscular immunization with a recombinant adenovirus. This study has identified a number of properties which may explain the strong immunogenicity of adenovirus vectors: (i) the ability to deliver large amounts of antigen into the lymphoid tissues, (ii) the ability to induce rapid expansion and migration of CD8(+) T cells throughout the lymphatics, and (iii) the ability to produce a sustained, high-level CD8(+) T-cell response.Entities:
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Year: 2003 PMID: 14645597 PMCID: PMC296052 DOI: 10.1128/jvi.77.24.13407-13411.2003
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103