| Literature DB >> 14644849 |
O Sánchez-Pernaute1, R Largo, E Calvo, M A Alvarez-Soria, J Egido, G Herrero-Beaumont.
Abstract
Intracavitary fibrin clots may initiate pannus formation and the immunopathology of RA. Two critical steps, probably host dependent, may determine the development of RA: an altered regulation of extravascular haemostasis or an aberrant reactivity of synovial fibroblasts to the adhered fibrin clots. Current treatments for RA target events downstream of fibrin deposition, perhaps agents acting at an earlier stage should be tried.Entities:
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Year: 2003 PMID: 14644849 PMCID: PMC1754399 DOI: 10.1136/ard.2003.011767
Source DB: PubMed Journal: Ann Rheum Dis ISSN: 0003-4967 Impact factor: 19.103