Literature DB >> 14643468

The role of the prefrontal cortex in object-place learning: a test of the attribute specificity model.

Raymond P Kesner1, Michael E Ragozzino.   

Abstract

In order to test an attribute specificity model of prefrontal cortex function, rats with lesions in the prelimbic-infralimbic (PL-IL) or anterior cingulate and precentral (AC-PC) subregions of the medial prefrontal cortex and controls were trained on an object-place paired associate task. Rats with AC-PC lesions acquired the task as readily as controls. In contrast, the PL-IL lesioned rats did not learn the task. Whenever higher order processing is required to solve a task, the data support an attribute-specificity model of prefrontal cortex function in that the PL-IL cortices support both object and place attribute information in a variety of tasks including object-place paired associate learning.

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Year:  2003        PMID: 14643468     DOI: 10.1016/j.bbr.2003.09.024

Source DB:  PubMed          Journal:  Behav Brain Res        ISSN: 0166-4328            Impact factor:   3.332


  20 in total

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