Literature DB >> 14643374

Synaptic slaughter in Alzheimer's disease.

Paul D Coleman1, Pamela J Yao.   

Abstract

Synaptic loss is currently established as the best neurobiological correlate of the cognitive deficits of Alzheimer's disease (AD) [Ann. Neurol. 27 (1990) 457; Ann. Neurol. 30 (1991) 572]. We provide evidence that still living neurons lose synapses in AD, in addition to the synapse loss due to death of neurons. We also provide evidence indicating that in addition to loss of synapses, synaptic function is also affected in AD by decrements in transcript species related to synaptic vesicle trafficking.

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Year:  2003        PMID： 14643374     DOI： 10.1016/j.neurobiolaging.2003.09.001

Source DB:  PubMed          Journal:  Neurobiol Aging        ISSN： 0197-4580            Impact factor:   4.673


  134 in total

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