Literature DB >> 14643357

Design and pharmacology of peptoids and peptide-peptoid hybrids based on the melanocortin agonists core tetrapeptide sequence.

Jerry Ryan Holder1, Rayna M Bauzo, Zhimin Xiang, Joseph Scott, Carrie Haskell-Luevano.   

Abstract

A series of N-substituted glycine oligomers (peptoids) and peptide-peptoid hybrids were synthesized based on the Ac-His-Phe-Arg-Trp-NH(2) tetrapeptide template. The compounds were pharmacologically characterized at the mouse melanocortin receptors (MC1R, MC3R-MC5R) for agonist activity.

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Year:  2003        PMID： 14643357     DOI： 10.1016/j.bmcl.2003.08.078

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  Hydrazone- and hydrazide-containing N-substituted glycines as peptoid surrogates for expedited library synthesis: application to the preparation of Tsg101-directed HIV-1 budding antagonists.

Authors:  Fa Liu; Andrew G Stephen; Catherine S Adamson; Karine Gousset; M Javad Aman; Eric O Freed; Robert J Fisher; Terrence R Burke
Journal:  Org Lett       Date:  2006-10-26       Impact factor: 6.005

2.  Structure-activity relationships of peptides incorporating a bioactive reverse-turn heterocycle at the melanocortin receptors: identification of a 5800-fold mouse melanocortin-3 receptor (mMC3R) selective antagonist/partial agonist versus the mouse melanocortin-4 receptor (mMC4R).

Authors:  Anamika Singh; Marvin Dirain; Rachel Witek; James R Rocca; Arthur S Edison; Carrie Haskell-Luevano
Journal:  J Med Chem       Date:  2013-03-25       Impact factor: 7.446

3.  Incorporation of a bioactive reverse-turn heterocycle into a peptide template using solid-phase synthesis to probe melanocortin receptor selectivity and ligand conformations by 2D 1H NMR.

Authors:  Anamika Singh; Andrzej Wilczynski; Jerry R Holder; Rachel M Witek; Marvin L Dirain; Zhimin Xiang; Arthur S Edison; Carrie Haskell-Luevano
Journal:  J Med Chem       Date:  2011-02-09       Impact factor: 7.446

4.  Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa1-Arg-(pI)DPhe-Xaa4-NH2.

Authors:  Skye R Doering; Katie T Freeman; Sathya M Schnell; Erica M Haslach; Marvin Dirain; Ginamarie Debevec; Phaedra Geer; Radleigh G Santos; Marc A Giulianotti; Clemencia Pinilla; Jon R Appel; Robert C Speth; Richard A Houghten; Carrie Haskell-Luevano
Journal:  J Med Chem       Date:  2017-05-15       Impact factor: 7.446

5.  Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1.

Authors:  Fa Liu; Jung-Eun Park; Wen-Jian Qian; Dan Lim; Andrej Scharow; Thorsten Berg; Michael B Yaffe; Kyung S Lee; Terrence R Burke
Journal:  Chembiochem       Date:  2012-05-08       Impact factor: 3.164

Review 6.  Solid-phase synthesis of N-substituted glycine oligomers (alpha-peptoids) and derivatives.

Authors:  Adrian S Culf; Rodney J Ouellette
Journal:  Molecules       Date:  2010-08-04       Impact factor: 4.411

7.  Short Tryptamine-Based Peptoids as Potential Therapeutics for Microbial Keratitis: Structure-Function Correlation Studies.

Authors:  Ghayah Bahatheg; Rajesh Kuppusamy; Muhammad Yasir; David StC Black; Mark Willcox; Naresh Kumar
Journal:  Antibiotics (Basel)       Date:  2022-08-08
  7 in total

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