Literature DB >> 14643339

1-aryl-6,7-methylenedioxy-3H-quinazolin-4-ones as anticonvulsant agents.

Maria Zappalà1, Silvana Grasso, Nicola Micale, Giuseppe Zuccalà, Frank S Menniti, Guido Ferreri, Giovambattista De Sarro, Carlo De Micheli.   

Abstract

A set of novel 1-aryl-6,7-methylenedioxy-3H-quinazolin-4-(thi)ones (3a-f) has been designed and screened as anticonvulsant agents in DBA/2 mice. The new compounds are provided with anticonvulsant properties comparable to those of GYKI 52466. To clarify the mode of action, their affinity for the quinazolinone/2,3-benzodiazepine site of the AMPA receptor complex has been assayed.

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Year:  2003        PMID： 14643339     DOI： 10.1016/j.bmcl.2003.09.032

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  A correlation study of biological activity and molecular docking of Asp and Glu linked bis-hydrazones of quinazolinones.

Authors:  H K Kumara; R Suhas; D M Suyoga Vardhan; M Shobha; D Channe Gowda
Journal:  RSC Adv       Date:  2018-03-16       Impact factor: 4.036

2.  Molecular Docking and Anticonvulsant Activity of Newly Synthesized Quinazoline Derivatives.

Authors:  Hatem A Abuelizz; Rabab El Dib; Mohamed Marzouk; El-Hassane Anouar; Yousreya A Maklad; Hanan N Attia; Rashad Al-Salahi
Journal:  Molecules       Date:  2017-06-30       Impact factor: 4.411

3.  Synthesis, Modelling, and Anticonvulsant Studies of New Quinazolines Showing Three Highly Active Compounds with Low Toxicity and High Affinity to the GABA-A Receptor.

Authors:  Mohamed F Zayed; Saleh K Ihmaid; Hany E A Ahmed; Khaled El-Adl; Ahmed M Asiri; Abdelsattar M Omar
Journal:  Molecules       Date:  2017-01-24       Impact factor: 4.411

4.  Synthesis of a Pyrrolo[1,2-a]quinazoline-1,5-dione Derivative by Mechanochemical Double Cyclocondensation Cascade.

Authors:  Vanessza Judit Kolcsár; György Szőllősi
Journal:  Molecules       Date:  2022-09-02       Impact factor: 4.927

5.  Synthesis, Characterization, and Anti-Inflammatory Activity of Newer Quinazolinone Analogs.

Authors:  Chatrasal Singh Rajput; Shiwani Singhal
Journal:  J Pharm (Cairo)       Date:  2013-01-17

6.  Synthesis and anticonvulsant activity of some quinazolin-4-(3H)-one derivatives.

Authors:  Hanan Georgey; Nagwa Abdel-Gawad; Safinaz Abbas
Journal:  Molecules       Date:  2008       Impact factor: 4.411
  6 in total

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