Literature DB >> 14643332

Novel non-vanilloid VR1 antagonist of high analgesic effects and its structural requirement for VR1 antagonistic effects.

Young-Ger Suh1, Yong-Sil Lee, Kyung-Hoon Min, Ok-Hui Park, Ho-Sun Seung, Hee-Doo Kim, Hyoung-Geun Park, J- Yeon Choi, Jeewoo Lee, Sang-Wook Kang, Uh-taek Oh, Jae-yeon Koo, Yung-Hyup Joo, Sun-Young Kim, Jin Kwan Kim, Young Ho Park.   

Abstract

A novel non-vanilloid VR1 antagonist consisting of a new vanilloid equivalent exhibits excellent analgesic effects as well as highly potent antagonistic activities in both capsaicin single channel and calcium uptake assays. In addition, the structural requirement for the vanilloid equivalent of the potent VR1 antagonist has also been elucidated.

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Year:  2003        PMID： 14643332     DOI： 10.1016/j.bmcl.2003.09.024

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Dynamic afferent synapses to decision-making networks improve performance in tasks requiring stimulus associations and discriminations.

Authors:  Mark A Bourjaily; Paul Miller
Journal:  J Neurophysiol       Date:  2012-03-28       Impact factor: 2.714

Review 2.  The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not.

Authors:  Andrej A Romanovsky; Maria C Almeida; Andras Garami; Alexandre A Steiner; Mark H Norman; Shaun F Morrison; Kazuhiro Nakamura; Jeffrey J Burmeister; Tatiane B Nucci
Journal:  Pharmacol Rev       Date:  2009-09-11       Impact factor: 25.468

3.  Contributions of different modes of TRPV1 activation to TRPV1 antagonist-induced hyperthermia.

Authors:  Andras Garami; Yury P Shimansky; Eszter Pakai; Daniela L Oliveira; Narender R Gavva; Andrej A Romanovsky
Journal:  J Neurosci       Date:  2010-01-27       Impact factor: 6.167
  3 in total

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