Literature DB >> 14643317

4-(4-alkylpiperazin-1-yl)phenyl group: a novel class of basic side chains for selective estrogen receptor modulators.

Nobuhide Watanabe1, Hiroshi Nakagawa, Akihisa Ikeno, Hisao Minato, Chie Kohayakawa, Jun-ichi Tsuji.   

Abstract

In the structure-activity relationships of spiro[indene-1,1'-indane] series, the 4-(4-alkylpiperazin-1-yl)phenyl group was found to be functionally equipotent to the 4-(1-piperidinoethoxy)phenyl group, the most widely used basic side chain in selective estrogen receptor modulators.

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Year:  2003        PMID: 14643317     DOI: 10.1016/j.bmcl.2003.09.049

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  [3,3]-Sigmatropic rearrangement/5-exo-dig cyclization reactions of benzyl alkynyl ethers: synthesis of substituted 2-indanones and indenes.

Authors:  Armen A Tudjarian; Thomas G Minehan
Journal:  J Org Chem       Date:  2011-03-25       Impact factor: 4.354

2.  Synthesis of Spiroindenyl-2-Oxindoles through Palladium-Catalyzed Spirocyclization of 2-Bromoarylamides and Vinyl Bromides.

Authors:  Shuai Yang; Yanghui Zhang
Journal:  Molecules       Date:  2021-12-10       Impact factor: 4.411

  2 in total

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