BACKGROUND: Neurocognitive deficits and symptoms of schizotypal personality disorder are both elevated in the first-degree relatives of schizophrenic patients, but their relationship to each other and their potential common genetic source remain unclear. METHODS: Fifty unaffected co-twins of schizophrenic patients and 123 control twins were assessed with a neuropsychological battery and structured clinical interviews. RESULTS: Working memory was influenced by genetic risk for schizophrenia but not schizotypal symptoms. Nearly all other domains were influenced by schizotypy symptoms but only in the co-twins of schizophrenic patients. Schizotypy symptoms in the absence of a family history did not seem to be related to impaired neurocognitive functioning. CONCLUSIONS: Schizotypy symptoms in those with genetic risk for schizophrenia are associated with increased risk for cognitive deficits. Some neurocognitive deficits might covary with subpsychotic symptoms due to a shared genetic factor. Community-ascertained schizotypal individuals might not be appropriate for modeling underlying genetic risk for schizophrenia.
BACKGROUND:Neurocognitive deficits and symptoms of schizotypal personality disorder are both elevated in the first-degree relatives of schizophrenicpatients, but their relationship to each other and their potential common genetic source remain unclear. METHODS: Fifty unaffected co-twins of schizophrenicpatients and 123 control twins were assessed with a neuropsychological battery and structured clinical interviews. RESULTS: Working memory was influenced by genetic risk for schizophrenia but not schizotypal symptoms. Nearly all other domains were influenced by schizotypy symptoms but only in the co-twins of schizophrenicpatients. Schizotypy symptoms in the absence of a family history did not seem to be related to impaired neurocognitive functioning. CONCLUSIONS: Schizotypy symptoms in those with genetic risk for schizophrenia are associated with increased risk for cognitive deficits. Some neurocognitive deficits might covary with subpsychotic symptoms due to a shared genetic factor. Community-ascertained schizotypal individuals might not be appropriate for modeling underlying genetic risk for schizophrenia.
Authors: Alice M Saperstein; Rebecca L Fuller; Matthew T Avila; Helene Adami; Robert P McMahon; Gunvant K Thaker; James M Gold Journal: Schizophr Bull Date: 2006-05-10 Impact factor: 9.306
Authors: William S Stone; Anthony J Giuliano; Ming T Tsuang; David L Braff; Kristin S Cadenhead; Monica E Calkins; Dorcas J Dobie; Stephen V Faraone; Robert Freedman; Michael F Green; Tiffany A Greenwood; Raquel E Gur; Ruben C Gur; Gregory A Light; Jim Mintz; Keith H Nuechterlein; Ann Olincy; Allen D Radant; Andrea H Roe; Nicholas J Schork; Larry J Siever; Jeremy M Silverman; Neal R Swerdlow; Alison R Thomas; Debby W Tsuang; Bruce I Turetsky; Larry J Seidman Journal: Schizophr Res Date: 2011-02-01 Impact factor: 4.939
Authors: Raquel E Gur; Monica E Calkins; Ruben C Gur; William P Horan; Keith H Nuechterlein; Larry J Seidman; William S Stone Journal: Schizophr Bull Date: 2006-11-13 Impact factor: 9.306
Authors: Zainab Delawalla; Deanna M Barch; Jennifer L Fisher Eastep; Emily S Thomason; Melissa J Hanewinkel; Paul A Thompson; John G Csernansky Journal: Schizophr Bull Date: 2006-05-19 Impact factor: 9.306
Authors: Chandlee C Dickey; Robert W McCarley; Margaret A Niznikiewicz; Martina M Voglmaier; Larry J Seidman; Sunnie Kim; Martha E Shenton Journal: Schizophr Res Date: 2005-10-15 Impact factor: 4.939
Authors: S Kristian Hill; Margret S H Harris; Ellen S Herbener; Mani Pavuluri; John A Sweeney Journal: Schizophr Bull Date: 2008-04-29 Impact factor: 9.306
Authors: William P Horan; David L Braff; Keith H Nuechterlein; Catherine A Sugar; Kristin S Cadenhead; Monica E Calkins; Dorcas J Dobie; Robert Freedman; Tiffany A Greenwood; Raquel E Gur; Ruben C Gur; Gregory A Light; James Mintz; Ann Olincy; Allan D Radant; Nicholas J Schork; Larry J Seidman; Larry J Siever; Jeremy M Silverman; William S Stone; Neal R Swerdlow; Debbie W Tsuang; Ming T Tsuang; Bruce I Turetsky; Michael F Green Journal: Schizophr Res Date: 2008-04-11 Impact factor: 4.939