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Literature DB >> 14643079

Using conditional mutagenesis to study the brain.

Alexei Morozov¹, Christoph Kellendonk, Eleanor Simpson, Francois Tronche.

Abstract

Conditional genetic modifications are used to determine how individual molecules contribute to the function of defined neuronal circuits in the mouse brain. Among various techniques for these genetic modifications, the tetracycline transactivator and the Cre-loxP systems have proved to be most successful in recent years. Here we describe the basic principles, recent developments, and potential applications of these methodologies. We discuss their impact on the study of general brain function and their use for modeling different brain disorders.

Entities: Disease Species

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Year: 2003 PMID： 14643079 DOI： 10.1016/s0006-3223(03)00467-0

Source DB: PubMed Journal: Biol Psychiatry ISSN： 0006-3223 Impact factor: 13.382

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Cited

25 in total

1. Cannabinoid agonists differentially substitute for the discriminative stimulus effects of Delta(9)-tetrahydrocannabinol in C57BL/6J mice.

Authors: Lance R McMahon; Brett C Ginsburg; R J Lamb
Journal: Psychopharmacology (Berl) Date: 2007-08-03 Impact factor: 4.530

Review 2. Animal models of bipolar disorder and mood stabilizer efficacy: a critical need for improvement.

Authors: Todd D Gould; Haim Einat
Journal: Neurosci Biobehav Rev Date: 2007-05-31 Impact factor: 8.989

Review 3. Knock-out and transgenic mouse models of tauopathies.

Authors: Franziska Denk; Richard Wade-Martins
Journal: Neurobiol Aging Date: 2007-06-22 Impact factor: 4.673

Review 4. Better understanding of mechanisms of schizophrenia and bipolar disorder: from human gene expression profiles to mouse models.

Authors: Chi-Ying Lin; Akira Sawa; Hanna Jaaro-Peled
Journal: Neurobiol Dis Date: 2011-09-03 Impact factor: 5.996

10. In ovo RNAi opens new possibilities for temporal and spatial control of gene silencing during development of the vertebrate nervous system.

Authors: Thomas Baeriswyl; Esther T Stoeckli
Journal: J RNAi Gene Silencing Date: 2006-02-28

Using conditional mutagenesis to study the brain.

1. Cannabinoid agonists differentially substitute for the discriminative stimulus effects of Delta(9)-tetrahydrocannabinol in C57BL/6J mice.

Review 2. Animal models of bipolar disorder and mood stabilizer efficacy: a critical need for improvement.

Review 3. Knock-out and transgenic mouse models of tauopathies.

Review 4. Better understanding of mechanisms of schizophrenia and bipolar disorder: from human gene expression profiles to mouse models.

5. Selective knockout of the casein kinase 2 in d1 medium spiny neurons controls dopaminergic function.

Review 6. Usefulness of knockout mice to clarify the role of the opioid system in chronic pain.

7. Wakefulness affects synaptic and network activity by increasing extracellular astrocyte-derived adenosine.

8. Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss.

9. The Use of Lentiviral Vectors and Cre/loxP to Investigate the Function of Genes in Complex Behaviors.

10. In ovo RNAi opens new possibilities for temporal and spatial control of gene silencing during development of the vertebrate nervous system.