Literature DB >> 14643055

Conversion from white to brown adipocytes: a strategy for the control of fat mass?

Claire Tiraby1, Dominique Langin.   

Abstract

Understanding the mechanisms governing the acquisition of white and brown adipocyte phenotypes might have implications for the physiopathology of, and therapeutic strategies for obesity. Peroxisome proliferator-activated recetor gamma (PPARgamma) and its coactivators, PGC-1alpha and SRC-1, influence brown adipocyte metabolism and development. Ectopic expression of PGC-1alpha induces the expression of brown adipocyte genes in human white adipocytes. The changes in gene expression promote stimulation of fatty acid oxidation. There is now evidence to support the concept of an alteration in energy balance through a conversion of white to brown adipose tissue.

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Year:  2003        PMID： 14643055     DOI： 10.1016/j.tem.2003.10.001

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  35 in total

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Review 2.  Peroxisome proliferator-activated receptor-delta, a regulator of oxidative capacity, fuel switching and cholesterol transport.

Authors:  C Fürnsinn; T M Willson; B Brunmair
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Review 5.  Mitochondrial (dys)function in adipocyte (de)differentiation and systemic metabolic alterations.

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7.  Fatty acid-induced mitochondrial uncoupling in adipocytes is not a promising target for treatment of insulin resistance unless adipocyte oxidative capacity is increased.

Authors:  K N Frayn; D Langin; F Karpe
Journal:  Diabetologia       Date:  2007-12-21       Impact factor: 10.122

8.  Increased fat:carbohydrate oxidation ratio in Il1ra (-/-) mice on a high-fat diet is associated with increased sympathetic tone.

Authors:  D Chida; O Hashimoto; M Kuwahara; H Sagara; T Osaka; H Tsubone; Y Iwakura
Journal:  Diabetologia       Date:  2008-07-02       Impact factor: 10.122

9.  Autophagy regulates adipose mass and differentiation in mice.

Authors:  Rajat Singh; Youqing Xiang; Yongjun Wang; Kiran Baikati; Ana Maria Cuervo; Yen K Luu; Yan Tang; Jeffrey E Pessin; Gary J Schwartz; Mark J Czaja
Journal:  J Clin Invest       Date:  2009-10-12       Impact factor: 14.808

10.  Impaired control of body cooling during heterothermia represents the major energetic constraint in an aging non-human primate exposed to cold.

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Journal:  PLoS One       Date:  2009-10-23       Impact factor: 3.240
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