OBJECTIVES: Chronic stress has been associated with impaired response to influenza vaccination in the elderly. This study investigated whether mild, intermittent stress experienced by young, healthy adults has a similar effect. METHODS: Antibody and psychological status were determined prevaccination and 5 weeks and 5 months later; a fourfold increase in antibody to at least one viral strain was considered protective. RESULTS: At 5 months, unprotected participants reported significantly more life events and tended to report more perceived stress than those who were protected. CONCLUSIONS: Psychological stress is detrimental to long-term maintenance of antibody levels following vaccination in young, healthy adults.
OBJECTIVES: Chronic stress has been associated with impaired response to influenza vaccination in the elderly. This study investigated whether mild, intermittent stress experienced by young, healthy adults has a similar effect. METHODS: Antibody and psychological status were determined prevaccination and 5 weeks and 5 months later; a fourfold increase in antibody to at least one viral strain was considered protective. RESULTS: At 5 months, unprotected participants reported significantly more life events and tended to report more perceived stress than those who were protected. CONCLUSIONS: Psychological stress is detrimental to long-term maintenance of antibody levels following vaccination in young, healthy adults.
Authors: Brooke N Jenkins; John F Hunter; Marie P Cross; Amanda M Acevedo; Sarah D Pressman Journal: J Psychosom Res Date: 2017-11-06 Impact factor: 3.006
Authors: Jacqueline W Mays; Michael T Bailey; John T Hunzeker; Nicole D Powell; Tracey Papenfuss; Erik A Karlsson; David A Padgett; John F Sheridan Journal: J Immunol Date: 2010-01-18 Impact factor: 5.422
Authors: Kate M Edwards; Meredith A Pung; Lianne M Tomfohr; Michael G Ziegler; John P Campbell; Mark T Drayson; Paul J Mills Journal: Vaccine Date: 2012-08-22 Impact factor: 3.641
Authors: E Kosor Krnic; A Gagro; D Kozaric-Kovacic; M Vilibic; M Grubisic-Ilic; V Folnegovic-Smalc; V Drazenovic; E Cecuk-Jelicic; I Gjenero-Margan; I Kuzman; T Jeren; A Sabioncello; V Kerhin-Brkljacic; B Kaic; A Markotic; K Gotovac; S Rabatic; G Mlinaric-Galinovic; D Dekaris Journal: Clin Exp Immunol Date: 2007-05-18 Impact factor: 4.330