| Literature DB >> 14642852 |
Krzysztof Tokarski1, Agnieszka Zahorodna, Bartosz Bobula, Grzegorz Hess.
Abstract
In the CA1 area of rat hippocampal slices, a combined application of 5-CT, a potent 5-HT(1A) and 5-HT(7) receptor agonist, and WAY 100635, a selective 5-HT(1A) receptor antagonist, resulted in a reversible increase of the CA1 extracellular population spike amplitude. In whole-cell recording from identified pyramidal neurons, the effects of 5-CT applied in the presence of WAY 100635 involved a reduction of the slow afterhyperpolarization (sAHP) and the frequency adaptation of action potential firing, which could be blocked by a specific 5-HT(7) receptor antagonist SB 269970. The results indicate that the activation of 5-HT(7) receptors increases the excitability of hippocampal CA1 pyramidal cells.Entities:
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Year: 2003 PMID： 14642852 DOI： 10.1016/j.brainres.2003.09.015
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252