Literature DB >> 14641891

Correlations between parameters in risk models: estimation and propagation of uncertainty by Markov Chain Monte Carlo.

A E Ades1, G Lu.   

Abstract

Monte Carlo simulation has become the accepted method for propagating parameter uncertainty through risk models. It is widely appreciated, however, that correlations between input variables must be taken into account if models are to deliver correct assessments of uncertainty in risk. Various two-stage methods have been proposed that first estimate a correlation structure and then generate Monte Carlo simulations, which incorporate this structure while leaving marginal distributions of parameters unchanged. Here we propose a one-stage alternative, in which the correlation structure is estimated from the data directly by Bayesian Markov Chain Monte Carlo methods. Samples from the posterior distribution of the outputs then correctly reflect the correlation between parameters, given the data and the model. Besides its computational simplicity, this approach utilizes the available evidence from a wide variety of structures, including incomplete data and correlated and uncorrelated repeat observations. The major advantage of a Bayesian approach is that, rather than assuming the correlation structure is fixed and known, it captures the joint uncertainty induced by the data in all parameters, including variances and covariances, and correctly propagates this through the decision or risk model. These features are illustrated with examples on emissions of dioxin congeners from solid waste incinerators.

Entities:  

Year:  2003        PMID: 14641891     DOI: 10.1111/j.0272-4332.2003.00386.x

Source DB:  PubMed          Journal:  Risk Anal        ISSN: 0272-4332            Impact factor:   4.000


  4 in total

Review 1.  Systems biology: perspectives on multiscale modeling in research on endocrine-related cancers.

Authors:  Robert Clarke; John J Tyson; Ming Tan; William T Baumann; Lu Jin; Jianhua Xuan; Yue Wang
Journal:  Endocr Relat Cancer       Date:  2019-06       Impact factor: 5.678

2.  Some Health States Are Better Than Others: Using Health State Rank Order to Improve Probabilistic Analyses.

Authors:  Jeremy D Goldhaber-Fiebert; Hawre J Jalal
Journal:  Med Decis Making       Date:  2015-09-16       Impact factor: 2.583

3.  Illicit and pharmaceutical drug consumption estimated via wastewater analysis. Part B: placing back-calculations in a formal statistical framework.

Authors:  Hayley E Jones; Matthew Hickman; Barbara Kasprzyk-Hordern; Nicky J Welton; David R Baker; A E Ades
Journal:  Sci Total Environ       Date:  2014-03-15       Impact factor: 7.963

4.  Kinetics of PTEN-mediated PI(3,4,5)P3 hydrolysis on solid supported membranes.

Authors:  Chun Liu; Sanghamitra Deb; Vinicius S Ferreira; Eric Xu; Tobias Baumgart
Journal:  PLoS One       Date:  2018-02-15       Impact factor: 3.240

  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.