Literature DB >> 1464111

In vitro replication study of modified bases in ras sequences.

H Kamiya1, T Sakaguchi, N Murata, M Fujimuro, H Miura, H Ishikawa, M Shimizu, H Inoue, S Nishimura, A Matsukage.   

Abstract

DNA templates containing a modified base (O6-methylguanine, 8-hydroxyguanine, xanthine or hypoxanthine) which was located in nucleotide sequences corresponding to the 12th or 61st codon of a ras gene were synthesized and deoxynucleotide incorporation opposite the lesions was investigated. The templates were replicated by Taq DNA polymerase, recombinant rat DNA polymerase beta and mouse DNA polymerase alpha-primase complex. Sequence analysis of the replicated products indicated selective incorporation of nucleotide(s) opposite a modified base, depending on the kind of base and of DNA polymerase. This system is very useful to obtain results of in vitro replication of modified bases in ras sequences.

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Year:  1992        PMID： 1464111     DOI： 10.1248/cpb.40.2792

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  18 in total

Review 1.  Survey and summary: The applications of universal DNA base analogues.

Authors:  D Loakes
Journal:  Nucleic Acids Res       Date:  2001-06-15       Impact factor: 16.971

2.  The N(8)-(2'-deoxyribofuranoside) of 8-aza-7-deazaadenine: a universal nucleoside forming specific hydrogen bonds with the four canonical DNA constituents.

Authors:  F Seela; H Debelak
Journal:  Nucleic Acids Res       Date:  2000-09-01       Impact factor: 16.971

3.  Artificial genetic systems: self-avoiding DNA in PCR and multiplexed PCR.

Authors:  Shuichi Hoshika; Fei Chen; Nicole A Leal; Steven A Benner
Journal:  Angew Chem Int Ed Engl       Date:  2010-07-26       Impact factor: 15.336

4.  Cyclobutane thymine dimers in a ras proto-oncogene hot spot activate the gene by point mutation.

Authors:  H Kamiya; N Murata; T Murata; S Iwai; A Matsukage; C Masutani; F Hanaoka; E Ohtsuka
Journal:  Nucleic Acids Res       Date:  1993-05-25       Impact factor: 16.971

5.  Biochemical characterization of a novel hypoxanthine/xanthine dNTP pyrophosphatase from Methanococcus jannaschii.

Authors:  J H Chung; J H Back; Y I Park; Y S Han
Journal:  Nucleic Acids Res       Date:  2001-07-15       Impact factor: 16.971

6.  Thermodynamic stability of base pairs between 2-hydroxyadenine and incoming nucleotides as a determinant of nucleotide incorporation specificity during replication.

Authors:  J Kawakami; H Kamiya; K Yasuda; H Fujiki; H Kasai; N Sugimoto
Journal:  Nucleic Acids Res       Date:  2001-08-15       Impact factor: 16.971

7.  The aflatoxin B(1) formamidopyrimidine adduct plays a major role in causing the types of mutations observed in human hepatocellular carcinoma.

Authors:  Maryann E Smela; Michelle L Hamm; Paul T Henderson; Constance M Harris; Thomas M Harris; John M Essigmann
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-14       Impact factor: 11.205

8.  Misincorporation of dAMP opposite 2-hydroxyadenine, an oxidative form of adenine.

Authors:  H Kamiya; T Ueda; T Ohgi; A Matsukage; H Kasai
Journal:  Nucleic Acids Res       Date:  1995-03-11       Impact factor: 16.971

9.  8-Hydroxyguanine in a mutational hotspot of the c-Ha-ras gene causes misreplication, 'action-at-a-distance' mutagenesis and inhibition of replication.

Authors:  Paweł Jałoszyński; Chikahide Masutani; Fumio Hanaoka; Ana Blanco Perez; Susumu Nishimura
Journal:  Nucleic Acids Res       Date:  2003-11-01       Impact factor: 16.971

10.  5-Nitroindole as an universal base analogue.

Authors:  D Loakes; D M Brown
Journal:  Nucleic Acids Res       Date:  1994-10-11       Impact factor: 16.971
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