Literature DB >> 14641104

Modelling the controls of the eukaryotic cell cycle.

B Novák1, J J Tyson.   

Abstract

The eukaryotic cell-division cycle is regulated by three modules that control G(1)/S, G(2)/M and meta/anaphase transitions. By using mathematical modelling, we show the dynamic characteristics of these individual modules and we also assemble them together into a comprehensive model of the eukaryotic cell-division cycle. With this comprehensive model, we also discuss the mechanisms by which different checkpoint pathways stabilize different cell-cycle states and inhibit the transitions that drive cell-cycle progression.

Mesh：

Year:  2003        PMID： 14641104     DOI： 10.1042/bst0311526

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  20 in total

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Authors:  Indrani Bose; Bhaswar Ghosh
Journal:  J Biosci       Date:  2007-08       Impact factor: 1.826

2.  Stable stochastic dynamics in yeast cell cycle.

Authors:  Yurie Okabe; Masaki Sasai
Journal:  Biophys J       Date:  2007-08-17       Impact factor: 4.033

3.  Model aggregation: a building-block approach to creating large macromolecular regulatory networks.

Authors:  Ranjit Randhawa; Clifford A Shaffer; John J Tyson
Journal:  Bioinformatics       Date:  2009-10-29       Impact factor: 6.937

4.  Stochastic control of proliferation and differentiation in stem cell dynamics.

Authors:  Zheng Sun; Natalia L Komarova
Journal:  J Math Biol       Date:  2014-10-16       Impact factor: 2.259

5.  Model composition for macromolecular regulatory networks.

Authors:  Ranjit Randhawa; Clifford A Shaffer; John J Tyson
Journal:  IEEE/ACM Trans Comput Biol Bioinform       Date:  2010 Apr-Jun       Impact factor: 3.710

6.  Stochastic modeling of stem-cell dynamics with control.

Authors:  Zheng Sun; Natalia L Komarova
Journal:  Math Biosci       Date:  2012-08-31       Impact factor: 2.144

7.  Navigating neocortical neurogenesis and neuronal specification: a positional information system encoded by neurogenetic gradients.

Authors:  Bernhard Suter; Richard S Nowakowski; Pradeep G Bhide; Verne S Caviness
Journal:  J Neurosci       Date:  2007-10-03       Impact factor: 6.167

8.  Cell lineages and the logic of proliferative control.

Authors:  Arthur D Lander; Kimberly K Gokoffski; Frederic Y M Wan; Qing Nie; Anne L Calof
Journal:  PLoS Biol       Date:  2009-01-20       Impact factor: 8.029

9.  Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches.

Authors:  Sudin Bhattacharya; Lisl K M Shoda; Qiang Zhang; Courtney G Woods; Brett A Howell; Scott Q Siler; Jeffrey L Woodhead; Yuching Yang; Patrick McMullen; Paul B Watkins; Melvin E Andersen
Journal:  Front Physiol       Date:  2012-12-14       Impact factor: 4.566

10.  Towards predicting the response of a solid tumour to chemotherapy and radiotherapy treatments: clinical insights from a computational model.

Authors:  Gibin G Powathil; Douglas J A Adamson; Mark A J Chaplain
Journal:  PLoS Comput Biol       Date:  2013-07-11       Impact factor: 4.475
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